放射增敏剂甘氨双唑钠对鼻咽癌放射治疗的作用

Clinical Study of Radiosensitive Effect of CMNa on the Radiotherapy of Nasopharyngeal Carcinoma

目的:研究甘氨双唑钠(CMNa)对鼻咽癌放射治疗的增敏作用和不良反应。方法:40例鼻咽癌患者随机分为两组,增敏组(放射治疗+CMNa)20例,对照组(单纯放疗)20例,两组放射治疗方法和剂量相同。对照组病例进行常规放疗治疗,增敏组采取常规放疗同时使用CMNa。治疗结束后观察两组临床疗效及不良反应。结果:增敏组治疗结束时鼻咽原发灶和颈部淋巴结的完全消退率(CR率)或部分消退率(PR率)均高于对照组,P<0.05。增敏组鼻咽原发灶和颈部淋巴结达到CR和PR时所需要的放疗剂量均低于对照组,P<0.05。两组毒副反应比较,差异无显著性。结论:CMNa合并放疗治疗鼻咽癌有增敏作用,可提高肿瘤局部控制率,而不良反应无明显增加。

Objective：To study the radiosensitive effect and toxicity of CMNa on the radiotherapy of nasopharyngeal carcinoma. Methods：All 40 patients with nasopharyngeal carcinoma were randomly divided into enhancement group and control group,each with 20 cases.With the same radiation treatment program and the same dose,control group were treated with conventional radiation alone,while enhancement group were treated with conventional radiotherapy combined with CMNa.The clinical effects and side effects were observed after treatment.Results：The complete remission （CR） rate and the part regression （PR） rate of nasopharyngeal and neck lymph node in the enhancement group were significantly higher than those in control group.The doses of nasopharyngeal and neck lymph node by which the effects had reached CR or PR in the enhancement group were significantly lower than those in control group. Comparing the side effects,there was no significant difference between the two groups. Conclusion：CMNa could enhance radiosensitivity and raise the local control rate of nasopharyngeal carcinoma while without obvious toxicity.