谷氨酰胺与无乳糖配方奶喂养对早产儿坏死性小肠结肠炎的预防观察

Prevention of Glutamine and Non-Lactose Milk on Necrotizing Enterocolitis in Premature Infants

目的探讨给予早产儿谷氨酰胺及无乳糖配方乳后对早产儿坏死性小肠结肠炎预防作用。方法随机选取240例住入我院新生儿重症监护病房的早产极低出生体质量儿,分为A组、B组、C组、对照组各60例,喂养方式:A组:谷氨酰胺+早产儿配方奶,B组:无乳糖配方奶,C组:谷氨酰胺+无乳糖配方奶,对照组:早产儿配方奶。观察至出生后30 d,计算每组发生腹胀超过2 d的发生率及坏死性小肠结肠炎的发生率。结果 A组、B组、C组、对照组早产儿腹胀超过2 d的发病率分别为5.00%、6.67%、3.33%、8.33%,坏死性小肠结肠炎的发病率分别为3.33%、3.33%、1.66%、5.00%。结论通过早产儿的合理喂养,可降低早产儿腹胀超过2 d的发病率及坏死性小肠结肠炎的发病率。

Objective To observe the effect of glutamine and non-lactose milk on the prevention of necrotizing enterocolitis（NEC） in premature infants. Methods 240 cases of very low birth weight premature infants admitted in the neonatal intensive care unit were selected and divided into 4 groups. Group A was given glutamine and premature infant formula;Group B was given non-lactose milk;Group C was given glutamine and non-lactose milk;Control group was given premature infant formula. Results The incidence of group A,B,C and control group of premature infant abdominal distention for more than two days was 5.00%, 6.67%, 3.33%, 8.33%,respectively. The incidence of NEC was 3.33%, 3.33%, 1.66%, 5.00%,respectively. Conclusions It can reduce the incidence of premature abdominal distention for more than two days and NEC by the reasonable feeding premature infants.