抗肿瘤药物药效学的评价方法

Evaluation method for pharmacodynamics of antitumor drug

抗肿瘤药物的药效学研究是新药发现与开发的重要环节，通常是指从样品到活性检测至动物实验的各个阶段的工作．本文介绍了抗肿瘤药物筛选的分子靶点及其抗肿瘤药物的药效学研究的体外筛选方法和体内治疗作用的动物试验方法，同时总结了抗肿瘤新药药效学评价中需关注的问题，展望了抗肿瘤药物药效学研究趋势．

The study for Pharmacodynamic of anticancer drug is an important part to new drug discovery and development, which usually refers to the work from the activity detection of sample to the various stages of animal experiments. This article describes the molecular target for anticancer drug screening, the methods for pharmacodynamics of anticancer drug in vitro screening and the animal test methods for therapeutic effects in vivo, at the same time, summarizes to pay close attention to issues about pharmaco dynamic evaluation of anticancer drug, prospects research trends of phannacodynamics of anticancer drug.