四物汤联合叶酸、维生素B_(12)治疗急性脑梗死伴高同型半胱氨酸血症观察

Therapeutic Effect of Siwu Decoctions Combined with Folic Acid and Vitamin B12 in the Treatment of Acute Cerebral Infarction with Hyperhomocysteinemia

目的:观察四物汤治疗急性脑梗死伴高同型半胱氨酸血症(Hhcy)的临床疗效及其对血浆同型半胱氨酸(Hcy)水平的影响。方法:将急性脑梗死伴Hhcy的57例患者随机分为两组,两组均给予基础治疗,对照组28例加用叶酸5 mg po,tid,维生素B_(12)1 mg,im,qd治疗,观察组29例在对照组治疗基础上加用四物汤。治疗4周后,观察两组治疗前后神经功能缺损评分及临床疗效,检测治疗前后两组患者血浆Hcy含量。结果:治疗后两组神经功能缺损评分均有明显好转(P<0.05),治疗组疗效与评分均优于对照组(P<0.05);治疗后两组Hcy水平均有明显改善(P<0.05),且治疗组改善程度优于对照组(P<0.05)。两组用药期间均未发现药品不良反应,治疗后常规检查亦未发现异常。结论:四物汤联合叶酸、维生素B_(12)治疗急性脑梗死伴Hhcy效果优于单纯常规使用叶酸和维生素B_(12)。

Objective： To investigate the therapeutic effect of Siwu decoctions on acute cerebral infarction （ACI） and hyperhomo- eysteinemia （HCY）： Methods： Totally 57 patients with ACI and HCY were randomly divided into the control group （n = 28 ） and the treatment group （n = 29）. In the control group, the patients received folic acid 5mg, po, rid, vitamin Bl2 ling, im, qd, and the rou- tine treatment. In the treatment group, the patients received Siwu decoctions additionally. The neurological defect score, clinical effi- cacy and HCY levels were evaluated respectively before and after the treatment. Results： After the treatment, the neuological defect score in the two groups deceased significantly（ P 〈 0.05 ）. The clinical efficacy in the treatment group was better than that in the con- trol group（ P 〈 0.05 ）. The HCY levels in the two groups deceased significantly （P 〈 0.05 ）. The effect in the treatment group was bet- ter than that in the control group （P 〈 0.05 ）. No adverse reaction was found in the two groups during the treatment. The routine tests were normal after the treatment. Conclusion： Siwu decoctions is efficient in the treatment of patients with ACI and HCY.