自噬与肿瘤发生及治疗抵抗的相关研究进展

Autophagy in Tumorigenesis and Therapeutic Resistance

自噬是细胞通过溶酶体降解损伤的细胞器和蛋白,维持细胞内物质和能量平衡的途径。自噬在肿瘤发生发展的不同阶段扮演不同角色:肿瘤发生早期抑制细胞恶性转化,进展期维持或促进肿瘤生长。肿瘤治疗抵抗与压力诱导自噬水平改变有关,自噬抑制剂的应用或将成为肿瘤治疗的新手段。

Autophagy is an evolutionarily conserved lysosomal degradation pathway that eliminates cytosolic proteins,organelles and maintains mutrients and energy balance. Autophagy plays different role in tumorigenesis and progress：inhibition of malignant transformation in early stage,and maintenance and promotion of growth of tumor in advanced stage. Numerous preclinical studies have demonstrated that cancer therapeutic resistance is closely related to pressure inducing autophagy.Application of inhibitor of autophagy will give a new strategy for cancer therapy.