布拉酵母菌散辅助治疗婴儿胆汁淤积性肝病疗效观察

Observation of the Effect of Saccharomyces Boulardii on the Adjunctive Treatment of Cholestatic Liver Disease in Children

目的:观察布拉酵母菌散治疗婴儿胆汁淤积性肝病的临床疗效。方法:126例胆汁淤积性肝病患儿分为观察组和对照组各63例。对照组给予护肝、利胆退黄等基础治疗,观察组在对照组治疗基础上加用布拉酵母菌散,疗程均为4周。比较两组患儿黄疽消退、肝脾回缩时间以及肝功能指标的变化,总体评价其临床疗效。结果:治疗后两组惠儿在黄疸消退、肝脾回缩等均有明显好转,观察组好转时间较对照组明显缩短(P<0.05);治疗后,观察组血清肝功能TBIL、DBIL、TBA、ALP、GGT等指标均明显下降,除ALT,其他肝功能指标均优于对照组(P<0.05和P<0.01);观察组显效率、总有效率均明显高于对照组(P<0.01);巨细胞病毒感染引起的胆汁淤积性肝病患儿中,观察组不良反应发生率明显少于对照组(P<0.01)。结论:布拉酵母菌散联合基础治疗能改善胆汁淤积性肝病婴儿肝脏功能,加速黄疸消退,同时还能减轻治疗过程中的不良反应。

Objective：To observe and analyze the effect of saccharomyces boulardii on the therapy of cholestatic liver disease in children. Methods：126 cholestatic liver disease neonates were randomly divided into two groups： controlled group（receiving basal therapy） and observation group （ receiving the basal therapy based on the use of saccharomyces boulardii ）. After the two different treatments, the jaundice subsided, the retraction time as well as the indexes of liver function concentration were detected to observe and analyze the effect of bulashi yeast on the therapy of neonatal jaundice. Methods：The time of reduction was faster and the reduction of the jaundice subsided and the retraction time were better in the observation group than those of the controlled group（P〈0.05）. The liver function TBIL, DBIL, TBA, ALP, GGT were obviously decreased more significantly in the treatment group than those of the controlled group after treatment （P〈0.05）. Except for ALT, other liver function indexes were better than those of the controlled group（P〈0.05 or P〈0.01）. The efficiency and total effective rate were significantly higher but the adverse reaction was significantly fewer in the treatment group than those of the controlled group（P〈0.01）.Conclusion：Saccharomyces boulardii used to treat the cholestatic liver disease in children could improve their liver function, accelerate the jaundice and alleviate the adverse reaction during the treatment.