我院1308例药品不良反应报告分析

Analysis of 1 308 Adverse Drug Reaction Reports in Our Hospital

目的：了解我院药品不良反应（ADR）发生的特点及易发原因，为临床预防ADR和合理用药提供参考。方法： 对2009～2013年我院上报的1 308例ADR报告，按患者年龄、性别、给药途径、药品类别、ADR严重程度累及器官或系统及临床表现进行统计、分析。结果：70岁以上及51～60岁两个年龄段ADR患者构成比最高，抗菌药引发ADR比例最大（277例，21.18%），注射剂静脉滴注所致ADR构成比最高（950例，72.63%）；皮肤及其附件损害最为常见（302例，23.09%）。结论：临床应重视ADR的报告和监测工作，加强临床合理用药监管，以减少和避免ADR的发生。

Objective： To understand the characteristics,and reasons of adverse drug reactions to provide references for rational drug use in clinics.hospital during 2009 to 2013 were statistically analyzed in respect of age and sex,route of administration, drug varieties, classification of serious degree of ADR involved organs or systems and clinical manifestations.Methods：Among the reports,ADRs were more often seen in the patients aged above 70 years and 51 60 years.Antimicrobial drugs taking the lead caused ADRs reported in 277（21.18%） reports. ADRs reported in 950（72.63%） reports were induced by intravenous route and lesions of skin and its appendants were the most common presentations of ADR,which appeared in 302（23.09%） reports.Conclusion：Much more attention should be paid to the reporting and monitoring of adverse drug reactions. The management of rational drug use should be strengthened to reduce and avoid the occurrence of adverse drug reactions.