期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

高迁移率族蛋白B1：肝脏缺血再灌注损伤中的重要靶点 被引量：7

原文传递
导出
摘要 高迁移率族蛋白（highmobilitygroup，HMG）为几乎存在于所有真核细胞内的非组蛋白核蛋白。自首次发现HMGBI可释放至胞外介导炎症反应后，HMGBl作为一种重要炎症介质和促炎细胞因子引起国内外普遍重视。
作者 李晓璟 叶啟发 王彦峰 李玲 刘倩雯
机构地区 中南大学湘雅附属三医院卫生部移植医学工程技术研究中心器官移植科
出处 《中华医学杂志》 CAS CSCD 北大核心 2014年第10期793-796,共4页 National Medical Journal of China
基金 国家“十二五”卫生行业专项基金（2010020004） 中央高校基本科研业务费专项基金（114075） 武汉市科技攻关项目（201161038344-01）
关键词 高迁移率族蛋白B1 肝脏缺血再灌注损伤 靶点 介导炎症反应 促炎细胞因子 非组蛋白 炎症介质 核蛋白
分类号 R575 [医药卫生—消化系统]
  • 相关文献

参考文献37

  • 1KluneJR, Tsung A. Molecular biology of liver ischemial reperfusion injury: established mechanisms and recent advancements[J]. Surg Clin North Am,2010,90:665-677.
  • 2Lotze MT, Tracey KJ. High-mobility group box I protein (HMGBl) : nuclear weapon in the immune arsenal[J]. Nat Rev Immunol ,2005,5 :331 -342.
  • 3Banerjee S, de Freitas A, Friggeri A, et a]. Intraoellular HMGBI negatively regulates efferocytosis[J].J Irnmunol , 2011 , 187: 46864694.
  • 4Yang H, Hreggvidsdollir HS, Palmblad K, et a1. A critical cysteine is required for HMGB I binding to Toll-like receptor 4 and activation of macrophage cytokine release[J]. Proc Nail Acad Sci US A,2010,107:11942-11947.
  • 5Gong W, Zheng Y, Chao F, et al. The anti-inflammatory activity of HMGB I A box is enhanced when fused with C-terminal acidic tail[J].J Biomed Biotechnol,2010,2010:915234.
  • 6Dhupar R, KluneJlt , Evankovich 1, et al. lnterferon regulatory factor I mediates acetylation and release of high mobility group box I from hepatocytes during murine liver ischemia-reperfusion injury[J]. Shock,2011 ,35 :293-301.
  • 7Oh YJ, YounJH, n Y, et al. HMGBl is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism],J J.J Irnmunol ,2009,182 :5800-5809.
  • 8Liu A, Fang H, Dirsch 0, et al. Oxidation of HMGBI causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion[J]. PLoS One, 20 12,7 : e35379.
  • 9Ito I, FukazawaJ, Yoshida M. Post-translational methylation of high mobility group box I (HMGBI) causes its cytoplasmic localization in neutrophils[J].J BioI Chern, 2007 , 282: 16336- 16344.
  • 10Kazama H, Ricci .IE, Herndon .1M, et al. Induction of immunological tolerance by apoptotic cells requires caspase?dependent oxidation of high-mobility group box-l protein[J] . Immunity ,2008 ,29 :21-32.

二级参考文献9

  • 1赵敏,孟醒.谷氨酰胺对脂多糖血症大鼠热休克蛋白70和肿瘤坏死因子-α表达的影响[J].中国病理生理杂志,2005,21(8):1587-1589. 被引量：13
  • 2Singleton KD,Serkova NP, Beckey VE, et al. Glutamine attenuates lung injury and improves survival after sepsis:role of enhanced heat shock protein expression [ J ]. Crit Care Med, 2005,33(6) :1206 - 1213.
  • 3Pollheimer J, Zellner M, Eliasen MM, et al. Increased susceptibility of Glutamine - depleted monocytes to fever - range hyperthermia : the role of 70 - kDa heat shock protein [ J ]. Ann Surg ,2005,241 (2) :349 - 355.
  • 4Wischmeyer PE, Kahana M, Wolfson R, et al. Glutamine induces heat shock protein and protects against endotoxin shock in the rat[J]. J Appl Physiol,2001,90(6) :2403 -2410.
  • 5Villar J, Mendez - alvarez S, Heat shock proteins and ventilator- induced lung injury[ J]. Curr Opin Crit Care,2003,9(1):9 -14.
  • 6Stojadinovic A, Kiang J, Goldhill J, et al. Induction of the heat shock response prevents tissue injury during acute inflammation of the rat ileum [ J]. Crit Care Med, 1997,25 (2) :309 -317.
  • 7Chen G, Kelly C, Stokes K,et al. Induction of heat - shock protein72kDa expression is associated with attenuation of ischemia - reperfusion induced microvascular injury [ J ]. J Surg Res,1997,69(2) :435 -439.
  • 8Uehara K, Takahashi T, Fujii H, et al. The lower intestinal tract - specific induction of heme oxygenase - 1 by glutamine protects against endotoxemic intestinal injury[ J]. Crit Care Med ,2005,33 (2) :381 - 390.
  • 9Hayashi Y, Sawa Y, Fukuyama N, et al. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity [ J ]. Circulation, 2002,106 (20) : 2601 - 2607.

共引文献1

同被引文献67

  • 1Jin, Cheng,Zhang, Pei-Jian,Wu, Xiao-Min,Zhou, Bin,Li, Yong,Liu, Xin-Yan,Feng, Min,Tao, Li-De.Impact of hypoxic preconditioning on apoptosis and its possible mechanism in orthotopic liver autotransplantation in rats[J].Hepatobiliary & Pancreatic Diseases International,2009,8(1):40-45. 被引量：26
  • 2唐道林,康睿,肖献忠.晚期炎症介质HMGB1的病理生理作用[J].中国病理生理杂志,2005,21(7):1426-1430. 被引量：21
  • 3辜臻晟,盛耀华.人类防御素在眼科的研究进展[J].眼视光学杂志,2007,9(6):428-431. 被引量：1
  • 4Li J, Li R J, Lv GY, et al. The mechanisms and strategies to protect from hepatic ischemia-reperfusion injury[ J]. Eur Rev Med Pharmacol Sci, 2015,19 ( 11 ) :2036-2047.
  • 5Christopher MF, Ralph CQ, Gregory CW, et al. Characterization of microparticles after hepatic isehemia-reperfusion injury [J]. PLoS One, 2014, 9 (5) : 1-5. DOI: 10. 1371/journal. pone. 0097945. eColleetion 2014.
  • 6Thapalia BA, Zhou Z, Lin XH. Autophagy, a process within reperfusion injury: an update[ J]. Int J Clin Exp Pathol, 2014, 7 (12) : 8322-8341.
  • 7Mendes-Braz M, Elias-Miro M, Jimenez-Castro MB, et al. The current state of knowledge of hepatic ischemia-reperfusion injury based on its study in experimental models [ J ]. J Biomed Biotechnol, 2012,2012 : 1-20. DOI : 10.1155/2012/298657.
  • 8Wang KW. Autophagy and apoptosis in liver injury [ J ]. Cell Cycle, 2015, 14( 11 ) : 1631-1642. DOI: 10. 1080/15384101. 2015. 1038685.
  • 9Cursio R, Colosetti P, Gugenheim J. Autophagy and liver ischemia-reperfusion injury [ J ]. Biomed Res Int, 2015,2015 : 417590. DOI: 10.1155/2015/417590.
  • 10Tao XF, Wan XY, Xu YW, eta]. Dioscin attenuates hepatic ischemia-reperfusion injury in Rats through inhibition of oxidative- nitrative stress, inflammation and apoptosis [ J ]. Transplantation, 2014, 98(6) : 604-611. DOI: 10. 1097/TP. 000000000000262.

引证文献7

二级引证文献25

中华医学杂志
2014年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部