血清同型半胱氨酸高水平的老年高血压病患者尿微量白蛋白的变化

Changes of urinary microalbumin levels in elderly patients with essential hypertension and high homocysteine levels

目的:了解老年高血压病患者血清同型半胱氨酸(homocysteine,Hcy)高水平的老年高血压病患者尿微量白蛋白的变化。方法:对120例老年高血压病患者进行血清Hcy的测定及动态血压的测定,高Hcy组59例,正常Hcy组61例,比较两组尿微量白蛋白的水平。结果:高Hcy组患者尿微量白蛋白显著高于正常Hcy组[(22±4)μg/min vs.(15±4)μg/min,P<0.01]。结论:高Hcy组高血压病患者尿微量白蛋白升高,Hcy加重高血压病患者的肾损害。

AIM： To explore the changes of urinary microalbumin levels in elderly patients with essential hypertension with high homocysteine levels. METHODS： Serum homocysteine and ambulatory blood pressure were measured in 120 elderly patients with hypertension. The patients were divided into two groups： high Hcy group （n =59） and control group （n =61 ）, and urinary nficroalbumin was compared between groups. RESULTS： The urinary microalbumin in high Hcy group was higher than in control group [（22±4）μg/min vs. （15±4）μg/min,P〈0.01]. CONCLUSION： High urinary microalbumin in Hey group suggests that Hey increases renal damage in elderly patients with essential hypertension.