宁夏枸杞和运动训练对慢性心理应激大鼠的影响

The influence on the behavior of chronic psychological stress in rats by sports exercise and Ningxia medlar

目的:研究枸杞子和运动训练对慢性心理应激的大鼠体重、行为、血清皮质醇的影响,探讨枸杞和运动训练联合作用对慢性心理应激的大鼠的调节作用。方法:在建立慢性心理应激模型基础上,施加枸杞和运动训练进行干预,将大鼠随机分为8组:对照组、应激组、运动训练组、运动训练+应激组、枸杞组、枸杞+应激组、枸杞+运动组、枸杞+运动+应激组。分析宁夏枸杞和运动训练对慢性心理应激大鼠体重、行为、血清皮质醇的影响。结果:应激组大鼠体重增长值与其它各组比较明显降低(P<0.05);枸杞组、枸杞+运动组与对照组相比较,体重增长明显(P<0.05);应激组潜伏期和其它各组比明显延长(P<0.05),运动、枸杞和应激对大鼠潜伏期的影响存在交互作用,使大鼠的潜伏期减少(P<0.05)。应激组穿行格数与对照组、运动组、枸杞组、枸杞+应激组、枸杞+运动+应激组比较明显减少(P<0.05),枸杞和运动对大鼠穿行格数存在显著的交互作用,使大鼠的穿行格数增加(P<0.05)。应激组直立次数和对照组、枸杞组、运动组、枸杞+应激、枸杞+运动+应激组相比明显减少,差异有显著性(P<0.05),枸杞和运动对大鼠的直立次数存在显著的交互作用,使大鼠的直立次数增加(P<0.05)。应激组修饰时间和对照组、运动组、枸杞组、枸杞+运动组、枸杞+运动+应激组比较明显减少(P<0.05)。应激组大鼠皮质醇含量和其它各组比较明显升高(P<0.05),枸杞和应激对大鼠皮质醇含量之间存在显著的交互作用,使大鼠的皮质醇含量增加(P<0.05)。结论:①宁夏枸杞和运动训练能够调节因慢性心理应激引起的体重增长减缓状态,提高体重增长的速度。②宁夏枸杞和运动训练能改善慢性心理应激大鼠抑郁样的表现。③慢性心理应激能使大鼠的皮质醇含量增高,宁夏枸杞和运动训练能够降低由慢性心理应激引起的皮质醇含量的增高。

Objective：To research the influence on the rats weight,behavior and cortisol of chronically psychological stress of behavior and cortisol by sports exercise and medlar.It discusses the joint action of sports exercise and medlar of regulating chronically psychological stress of rats.Methods：The chronic psychological stress model was established.The intervention was performed by sports exercise and medlar.The rats were divided into 8 groups randomly：control group,stress group,sports exercise group,sports exercise with stress group,medlar group,medlar with stress group,medlar with sports exercise group and medlar with sports exercise with stress group.Analyze the influence on the rats weight,behavior and cortisol of chronically psychological stress of behavior and cortisol by sports exercise and medlar.Results：The growth rate of weight in stress group decreased sharply than any others（P＜0.05）.The weight increases more in Medlar group and Medlar with sports exercise group than the control group（P＜0.05）.The stress group has the longest latency period（P＜0.05）.Sports exercise,medlar and stress effect the latency period interactively which reduces it（P＜0.05）.Crawl lattices numbers of stress group decreased significantly than control group,medlar group,sports exercise group,medlar with stress group and medlar with sports exercise（P＜0.05）.Medlar and sports exercise effect the crawl lattices numbers which increases it（P＜0.05）.The erect numbers in stress group decreased significantly than control group,medlar group,sports exercise group,medlar with stress group and medlar with sports exercise（P＜0.05）.Medlar and sports exercise effect the erect numbers which increases it （P＜0.05）.The modification time in stress group decreased significantly than control group,medlar group,sports exercise group,medlar with stress group and medlar with sports exercise（P＜0.05）.The cortisol content in stress group rose significantly than other groups（P＜0.05）.Medlar and sports exercise effect the cortisol content which increases it（P＜0.05）.Conclusion：① Medlar and sports exercise would regulate the decrease in growth rate caused by chronic psychological stress and improve it.② Medlar and sports exercise would change the depression of rats caused by chronic psychological stress.③ The cortisol content of chronic psychological stress rats rises significantly.Medlar and sports exercise would reduce it.