摘要
目的探讨儿童狼疮性肾炎(LN)的临床、病理及免疫学特点。方法回顾性分析住院治疗的45例LN患儿的临床和病理资料及免疫学指标。结果 45例LN患儿中男6例、女39例,平均发病年龄(10.9±2.8)岁。临床表现为急性肾炎综合征型最常见,占42.2%,肾病综合征占31.1%。42例进行病理分型,其中Ⅱ型8例(17.8%),Ⅲ型2例(4.4%),Ⅳ型22例(48.9%),Ⅴ型1例(2.2%),Ⅴ+Ⅲ型3例(6.7%),Ⅴ+Ⅳ型6例(13.3%)。在治疗初期临床缓解率达91.1%,随访24个月15.0%复发。结论 LN患儿的临床表现具有多样性,肾脏病理复杂多变,部分患儿临床表现与肾脏病理表现不一致。
Objective To analyze the clinical and immunological features of 45 pediatric patients with lupus nephritis (LN). Methods Forty-five LN patients were included in this study. Clinical, pathological data and immunological parameters were retrospectively analyzed. Results Forty-five LN patients had 6 males and 39 females, with the mean onset age of (10.9 ± 2.8) years. Acute nephritis was the most common type, accounting for 42.2%. Nephrotic syndrome accounted for 31.1%. Renal biopsy showed class Ⅱ (17.8%), Ⅲ (4.4%), Ⅳ (48.9%), V (2.2%), V+Ⅲ (6.7%) and V+Ⅳ (13.3%) in 42 cases. The remission rate reached 91.1% in the early therapeutic stage, and 15.0% patients recurred after 24-month follow-up. Conclusions The clinical manifestations of LN children are diverse. The renal pathology is complex. The clinical manifestations in part of the children are not consistent with renal pathology.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2014年第3期246-249,共4页
Journal of Clinical Pediatrics
关键词
狼疮性肾炎
临床
病理
免疫学
儿童
lupus nephritis
clinical manifestations
pathology
immunological feature
child