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miR-150与临床疾病研究的新进展 被引量：19

New advances of miR-150 and diseases
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摘要 microRNA(miRNA)是一种新型的小分子非编码RNA,对基因表达具有非常重要的调控作用。miR-150是一个长度为22个核苷酸的非编码小分子RNA,定位于人类染色体19q13.33,主要通过调控其靶基因的表达,在免疫系统、造血系统发生、胚胎发育和干细胞分化中发挥重要作用,并在许多疾病中发生异常表达,提示miR-150与疾病的发生与发展密切相关。本文就miR-150在人体正常生理过程中的作用以及异常表达引起的机体变化和可能的作用机制作一综述。 MicroRNA （miRNA）is a novel type of non-coding RNA which can play very important roles in regulating gene expression. Early studies found that miR-150 is a 22 nt non-coding RNA, and located on Chromosome 19. It plays key roles in immune system, hematopoietic system progressive, embryonic development and stem cells differention by regulating the expression of its target mRNA. Recent investigations suggest that miR-150 expresses abnormally in different diseases. This reveals that miR-150 is closed related to the occurrence and development of many diseases. This article reviews the effect of miR-150 in human normal physiological processes, its abnormal expressions inducing changes in body and the possible mechanism involved.
作者 刘付梅 李祥勇 周克元
机构地区 广东医学院生物化学与分子生物学研究所
出处 《医学研究生学报》 CAS 北大核心 2014年第2期194-198,共5页 Journal of Medical Postgraduates
基金 国家自然科学基金(81172067) 东莞市高等院校科技计划一般项目(2011108102044) 湛江市科技攻关项目(2011C3108012)
关键词 miR-150 临床疾病 基因表达调控 miR-150 Clinical disease Gene expression regulation
分类号 Q344.13 [生物学—遗传学]
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参考文献28

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共引文献29

同被引文献92

  • 1陈少安,孟慧林.特拉唑嗪联合治疗前列腺炎的研究进展[J].泌尿外科杂志（电子版）,2013,5(4):1-3. 被引量：1
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引证文献19

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医学研究生学报
2014年 第2期

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