不同方案对322个夫精人工授精周期妊娠率的影响

Effects of different protocols on the success rate of pregnancy in 322 cycles of intrauterine insemination

目的目前临床上认为促排卵治疗可显著提高宫腔内人工授精(intrauterine insemination,IUI)的临床妊娠率。文中分析不同治疗方案对IUI临床妊娠率的影响。方法回顾性分析行IUI的189例患者,共322个治疗周期的临床资料,探讨应用自然周期(natrual circle,NC)组、克罗米芬(clomifene citrate,CC)+人绝经尿促性腺素(human menopausal gonadotrophin,HMG)组、CC组及来曲唑(letrozole,LE)+HMG四种不同治疗方案对临床妊娠率的影响。结果自然周期(natrual circle,NC)组、克罗米芬(Clomifene Citrate,CC)+人绝经尿促性腺素(human menopausal gonadotrophin,HMG)组、CC组及来曲唑(Letrozole,LE)+HMG组的临床妊娠率分别为6.30%、26.32%、11.11%、16.28%,4组妊娠率差异具有统计学意义(P<0.05);其中CC+HMG组较NC组妊娠率显著升高(P<0.05)。结论不同治疗方案对IUI妊娠率有影响,CC+HMG促排方案可显著提高IUI妊娠率。

Objective It is known that ovulation induction can significantly increase the pregnancy rate of intrauterine insem-ination （IUI）. This study analyzed the effects of different protocols on the pregnancy rate of IUI. Methods We retrospectively ana-lyzed the clinical data of 189 patients that underwent 322 cycles of IUI, and investigated the effects of natural cycle （ NC）, Clomifene Citrate （ CC ） , CC ＋ human menopausal gonadotrophin （HMG） , and Letrozole （ LE ） ＋ HMG on the rate of clinical pregnancy. Results The success rates of clinical pregnancy in the NC, CC, CC ＋ HMG, and LE ＋ HMG groups were 6.30%, 11. 11% , 26.32% , and 16.28% , respectively, with statistically significant differences among the four groups （P 〈 0.05 ）, and dramatically higher in the CC ＋ HMG than in the NC group （ P 〈 0.05 ）. Conclusion Different protocols have different effects on the pregnancy rate of IUI. Ovulation induction with CC/HMG can evidently improve the pregnancy rate of IUI.