过氧化物还原酶4在胃癌中的表达及其意义

Expression and significance of peroxiredoxin 4 in human gastric cancer

目的探讨过氧化物还原酶4(Prx 4)在胃癌组织中的表达及其临床意义。方法免疫组织化学法检测52例胃癌(A组)、20例胃不典型增生(B组)和33例胃炎(C组)组织中Prx 4的表达水平,分析其与胃癌临床病理学参数之间的关系。结果 A组Prx 4表达阳性率为90.4%,明显高于B组和C组的5.0%和9.1%(P<0.05)。Prx 4在胃癌组织中的表达与各临床病理参数之间均没有明显的相关性(P>0.05)。结论 Prx 4在胃癌组织中高表达,可能在胃癌的发病过程中起一定作用。

Objective To investigate the expression and significance of peroxiredoxin 4（Prx 4） in human gastric cancer. Methods Immunohistochemistry method was used to detect the expression of Prx 4 in 52 cases of gastric carcinoma tissues（group A）, 33 atypical hyperplasia tissues（group B） and 20 gastritis tissues （group C）. The correlation of Prx 4 expression and clinical parameters was analyzed. Results The positive rate of Prx 4 in group A was 90. 4~,which was higher than 5.0% and 9.1% in groups of B and C （P〈0. 05）. There were no obvious correlations between Prx 4 expression and clinicopathological parameters in gastric carcinoma （P〉0. 05）. Conclusion Prx 4 is highly expressed in gastric cancer, which mav plav a role in the oathogenesis of gastric cancer.