持续气道正压通气联合药物对阻塞性睡眠呼吸暂停低通气综合征患者高血压的影响

Clinical observation of continuous positive airway pressure combined with drugs in the treatment of patients with severe OSAHS accompanied with hypertension

目的观察持续气道正压通气(continuous positive airway pressure,CPAP)联合药物对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者高血压的影响。方法选择本院2009年7月至2013年1月确诊OSAHS合并高血压患者104例,随机分为实验组和对照组各52例,实验组给予CPAP配合降压药物治疗,对照组给予单纯降压药物治疗。观察两组治疗前后昼夜血压变化。结果治疗后实验组24 h平均收缩压(MSP)及平均舒张压(MDP)、白昼MSP及MDP、夜间MSP及MDP均较治疗前明显下降(P<0.05),且与对照组治疗后比较差异均有统计学意义(P<0.05)。最低血氧饱和度(SaO2)和睡眠呼吸暂停低通气指数(AHI)治疗组较治疗前明显改善(P<0.05),而对照组治疗前后差异无统计学意义。结论 CPAP结合药物是治疗OSAHS合并高血压的有效方法。

Objective： To observe the clinical effect of continuous positive airway pressure （CPAP） combined with drugs in the treatment of patients with severe OSAHS accompanied with hypertension. Methods ： 104 patients with severe OSAHS accompanied with hypertension were randomly divided into control group and CPAP group. In the control group, the patients underwent antihypertensive drugs while in experimental group, extra CPAP treatment waa applied concurrently. Blood pres- sure changes at day and night of the 2 groups were observed. Results： 24h average SBP and average DBP of experiment group at day and at night were significantly different from those of the control group （ P 〈 0.05 ）. Conclusion： CPAP is an effective way to cure OSAHS combined hypertension.