青柏祛疣汤对尖锐湿疣HPVDNA含量的影响

Diversification of content of HPV- DNA virus in condyloma acuminatum who treated with Qingbai Quyou

目的检测青柏祛疣汤对尖锐湿疣HPVDNA含量的影响。方法将110名符合标准的尖锐湿疣患者随机分为治疗组和对照组。治疗组应用中药治疗,对照组用5%咪喹莫特软膏治疗,收集治疗前和治疗2,4,8,12周后的病灶标本,利用PCR技术检测HPVDNA的含量。结果两组患者治疗前及治疗2、4周后尖锐湿疣病毒含量差异无显著性(P﹥0.05)。治疗8周后治疗组有42例患者(70.0%)病毒含量转阴,对照组有41例患者(84.0%)病毒转阴,两者比较差异无显著性(P﹥0.05)。两组患者采用不同方法治疗后局部HPV病毒DNA含量均较治疗前明显降低,治疗前后比较均有统计学意义;结论青柏祛疣汤能有效的治疗尖锐湿疣,并能明显降低HPV病毒DNA的含量。

Objective：To determine the diversification of content of HPV-DNA virus in condyloma acuminatum who treated with Qingbai Quyou; Methods：110 Condyloma Acuminatum were randomly divided into treatment group and control group. The treatment group used Qingbai Quyou, the control group was treated with 5% imiquimod cream （produced by Sichuan Ming Xin Pharmaceutical Co. Ltd.）, collect specimen of pretherapy、post-treatment of 2、4、8 and 12 weeks, every pore byimmunity drug was amplified by polymerase chainreaction （PCR）with fluorescence.Then analyse the dissi-milarity diversficaiton; Results： Two groups had no significant difference pretherapy （P 〉 0.05）. post-treatment of 8 weeks The negative rate of the treatment was 70%,and the control group was 84%, which had no significant difference （P 〉 0.05）. by different methods of post-treatment 8 weeks,the DNA levels of Two groups were significantly lower than pretherapy;Conclusion： Qing Bai Quyou is effective in treating condyloma acuminatum and significantly reduced HPV DNA content.