探索口腔内疼痛性冷水刺激时对眶额皮层激活的影响

Effects of nociceptivecoldon activation of orbitofrontal cortex during intraoral stimuli with water

目的:探索疼痛性冷水刺激口腔时脑功能活动的影响。方法:选取健康志愿者6例,利用水传递装置用4℃水刺激口腔,并以室温水组作为空白对照。并采集全脑血氧水平依赖对比的功能性磁共振成像(functional magnetic resonance imaging,fMRI)扫描数据。结果:与对照组比较,6例志愿者中冷水刺激均出现眶额皮层的显著激活。结论:发现了疼痛性冷刺激口腔时可激活与疼痛情绪有关的眶额皮层。

Objective： To explore effects of nociceptive coldon cerebral cortical activation during intraoral stimulus with water with functional magnetic resonance imaging（fMRI）. Methods： Six healthy volunteers were selected to receive 4℃ water intraoral stimuli through water-delivery, and block designed and blood oxygenation level-dependent （Bold） fMRI scan covering the whole brain were carded out. And 23℃ water L is as a control. Result： There was rebust activation in orbitofrontal cortex among 6 volunteers. Conclusions： The research show orbitofrontal cortex, which is related to human affective/emotion of pain, is activated by nociceptive cold during intraoral stimuli with water.