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A NOVEL APPLICATION OF A CLASSICAL METHOD FOR CALCULATING THE BASIC REPRODUCTIVE NUMBER, Ro FOR A GENDER AND RISK STRUCTURED TRANSMISSION DYNAMIC MODEL OF HUMAN PAPILLOMAVIRUS INFECTION

A NOVEL APPLICATION OF A CLASSICAL METHOD FOR CALCULATING THE BASIC REPRODUCTIVE NUMBER, Ro FOR A GENDER AND RISK STRUCTURED TRANSMISSION DYNAMIC MODEL OF HUMAN PAPILLOMAVIRUS INFECTION
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摘要 Mathematical models are increasingly being used in the evaluation of control strategies for infectious disease such as the vaccination program for the Human PapiUomavirus （HPV）. Here, an ordinary differential equation （ODE） transmission dynamic model for HPV is presented and analyzed. Parameter values for a gender and risk structured model are estimated by calibrating the model around the known prevalence of infection. The effect on gender and risk sub-group prevalence induced by varying the epidemiological parameters are investigated. Finally, the outcomes of this model are applied using a classical mathematical method for calculating R0 in a heterogeneous mixing population. Estimates for R0 under various gender and mixing scenarios are presented.
作者 KATY TOBIN CATHERINE COMISKEY
机构地区 Academic Unit of NeurologyTrinity College Dublin School of Nursing and MidwiferyTrinity College Dublin
出处 《International Journal of Biomathematics》 2013年第6期149-161,共13页 生物数学学报（英文版）
关键词 Transmission dynamic models HPV ODE SIR model R0 结构化模型 动态模型 病毒感染 性别 应用 风险 计算 传输
分类号 O175.13 [理学—基础数学] TP333.35 [自动化与计算机技术—计算机系统结构]
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International Journal of Biomathematics
2013年 第6期

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