Claudin蛋白在紧密连接中的作用机制及与疾病的关系

The effect mechanism of Claudin protein in tight junctions and the relationship with the disease

Claudin蛋白是组成细胞间紧密连接的一种跨膜蛋白,它的功能主要是调节屏障结构的渗透性。细胞间紧密连接的稳定性与Claudin蛋白间及Claudin蛋白与其他紧密连接蛋白间复杂的相互作用有关。Claudin蛋白的转录及表达的调节机制有磷酸化、去磷酸化等。人类很多疾病与Claudin蛋白的突变有关,至今为止,关于Claudin蛋白的了解不仅停留在紧密连接的组成部分,更多的是其调节方式及其与疾病发生的关系等方面的研究。本文作者对Claudin蛋白的结构、作用方式、与临床疾病的关系及其未来研究的展望作一综述。

Claudin proteins are composed of cells closely connection between a transmembrane protein, their function is mainly to adjust the permeability of barrier structure. The interactions between claudin proteins and other tight junction proteins are necessary for the stability of the tight junctions. There are many mechanisms of claudin protein transcription and expression regulation, such as phosphorylation and phosphorylation. Many diseases associated with the mutations of claudin protein, so far, we know about the claudin protein not only stay in the tightly coupled components, more is the control mode and its relationship with diseases such as research. In this paper, the authors make a review about the claudin protein structure and function way, and the relationship between clinical disease and its outlook of future research.