生长激素-胰岛素样生长因子-1轴在糖尿病肾病发生发展中的作用

GH/IGF-1's action for the pathogenesis of diabetic nephropathy

糖尿病肾病是糖尿病最常见的慢性并发症之一,但其发病机制目前并不是十分清楚。近年研究发现,肾小球足细胞损伤是糖尿病肾病发生发展的中心环节,而导致足细胞损伤的因素极其复杂,其中生长激素-胰岛素样生长因子-1轴在糖尿病肾病进展和足细胞损伤中发挥着重要作用。本文主要对近年的有关研究进展加以综述,以此引起研究者与临床医师的重视,为治疗及预防早期糖尿病肾病提供新思路。

Diabetic nephropathy (DN) is one of the most relevant diabetic complications. The pathogenesis is still poorly understood. In recent years, a large number of studies showed that podocyte injury is the central link in the development of DN. Podocyte injury can be caused by complex factors in which the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis plays an important role which has been demonstrated by a number of recent studies. This article is aimed to review the latest findings regarding as the role of in the pathogenesis of DN, and looking forward to offering the possibility of targeting the GH/IGF-1 axis for the prevention and treatment of DN.