血清胸苷激酶1在恶性肿瘤筛查和复发转移监测中的研究进展

Progress advances on serum thymidine kinase 1 in screening and monitoring of malignant tumor recurrence and metastasis

恶性肿瘤是目前死亡常见原因之一,检测合适的肿瘤标记物可以提高肿瘤的诊疗效率,用于早期筛查和治疗监测的血清学肿瘤标记是近年来肿瘤研究的热点。胸苷激酶1(TK1)是一种新型细胞增殖标记物,作为补救途径合成DNA的关键酶之一,其在实体肿瘤的疗效监测、早期诊断、预后随访中得到广泛的临床研究。现对TK1的结构、功能及其与恶性肿瘤的关系予以综述。

Malignant tumor is a leading cause of death in the world, identifying suitable biomarkers can improve the effectiveness of diagnosis and treatment. Therefore it is the current research focus on finding serum tumor biomarkers for health screening and clinical monitoring.Thymidine kinase 1, as a novel cell proliferation marker, is a salvage enzyme involved in DNA precursor synthesis. A serum form of TK1 has been widely tested in controlled clinical studies recently in solid tumors for monitoring the effect of therapies, prognosis, and follow-up. Here the structure, function of TK1 and its correlation with malignant tumors is summarized.