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NLRP1和NLRP3炎性体的研究进展 被引量：9

Research progress of the NLRP1,NLRP3 inflammasome
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摘要 炎性体作为一种新近发现的蛋白质复合物,其活化后可促进炎性因子的成熟与释放,在先天性免疫中发挥着重要的作用。本文就核苷酸结合寡聚化结构域样受体蛋白1(NLRP1)和3(NLRP3)炎性体的构成、激活机制及信号传导通路和相关的疾病做出综述,并对NLRP1和NLRP3炎性体与早产的关系做出推测。 Inflammasome as a newly discovered protein complexes which can activate promote the maturation and release inflammatory factors plays an important role in innate immunity response. The paper mainly reviewed about the composition, activation mechanism, the signal transduction pathways and the disease of nucleotide-binding oligomerization domain-like receptor protein 1 （NLRP1） and 3 （NLRP3）. And speculated the relationship between the inflammasome NLRP1, NLRP3 and preterm labor.
作者 原孟 尚丽新
机构地区 北京军区总医院妇产科
出处 《中华临床医师杂志（电子版）》 CAS 2013年第23期266-268,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 早产 先天性免疫应答 NLRP1 NLRP3 NLRP1 NLRP3 Premature birth Innate immunity response
分类号 R363 [医药卫生—病理学]
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参考文献37

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共引文献20

同被引文献151

引证文献9

二级引证文献52

中华临床医师杂志（电子版）
2013年 第23期

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