细胞毒性T淋巴细胞相关抗原4及其基因多态性在丙型病毒性肝炎中的研究进展

Research progress of the relationship between CTLA-4, CTLA-4 polymorphism and HCV infection

细胞毒性T淋巴细胞相关抗原4(CTLA-4)是淋巴细胞表面的一种与免疫信号传递有关的免疫球蛋白,与B7结合后能负调节活化的T淋巴细胞的功能,抗CTLA-4单克隆抗体能阻止这种负调节作用,CTLA-4基因多态性可影响CTLA-4的功能,对于不同个体免疫强度的差异起到关键作用。丙型肝炎病毒感染的自然清除及慢性化与感染者体内的CD4+及CD8+T淋巴细胞的免疫应答有密切关系,肝组织和外周血中HCV特异性CD8+T淋巴细胞的活性在决定慢性丙型肝炎干扰素治疗效果中起到十分重要的作用。所以,本文旨在综述CTLA-4及其基因多态性与丙型肝炎病毒感染的相关性。

CTLA-4 is a ligand protein molecular that related to immune signal transmission on the surface of lymph cell. It can down-regulate the function of the activated T cell when binding to B7. Anti-CTLA-4 antibody can block the down-regulation fimction of CTLA-4 to improve the reactivity of T lymph cell. CTLA-4 polymorphism can impact the function of CTLA-4, which plays a key role for the difference of immune strength in different individuals. Natural clearance of hepatitis C virus （HCV） and the progression towards chronic HCV infection are closely connected with the immune response of CD4＋ and CD8＋ T lymph cell. Intrahepatic and peripheral blood virus-specific CD8＋ T lymphocyte activity is associated with a response to combination IFN-a and ribavirin treatment among patients with chronic HCV infection. So the relationship between CTLA-4, CTLA-4 polymorphism and HCV infection was reviewed in this article.