结直肠癌肝转移切除术后肝内复发的治疗

The therapy for intrahepatic recurrence after hepatectomy of colorectal liver metastases

结直肠癌肝转移术后存在较高的肝内复发率。肝内复发影响了患者的远期生存,再次手术甚至多次手术能有效延长患者生存期,却不一定会增加围手术期并发症,可以成为首选的治疗方式。对于部分无法再次手术的患者,术前行化疗、栓塞、射频、单克隆抗体等辅助治疗,能有效提高肿物的可切除性,术后联合辅助治疗,能有效改善预后。

High risk of intrahepatic recurrence after hepatectomy of colorectal liver metastases impairs the long-term survival of these patients. Reoperation even multiple surgeries which would not necessarily increase the perioperative complications can effectively prolong survival and could be the first choice of treatment. For those who are not suitable for reoperation, preoperative chemotherapy, embolization, radio frequency ablation, monoclonal antibodies and other adjuvant therapy can effectively improve the resectability of the tumor. In addition, postoperative adjuvant chemotherapy could apparently improve the prognosis.