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MMP-14、MMP-2在喉癌中的表达及临床意义 被引量：1

Clinical expression and significance of MMP-14, MMP-2 in laryngeal cancer
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摘要 目的探讨基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-14（MMP-14）在喉癌中的表达及意义。方法应用流式细胞术检测40例喉癌组织、28例癌旁组织及15例喉部正常粘膜组织中MMP-2、MMP-14的表达。结果MMP-14、MMP-2蛋白在喉癌组织中的表达量均高于正常粘膜组织（P〈0．05）。在喉癌组织中，MMP-14、MMP-2蛋白与淋巴结是否转移、临床分期及病理组织学分级密切相关（P〈0．05）。结论在喉癌组织中MMP-14、MMP-2蛋白高表达可能与喉癌的发生有关。联合监测喉癌中MMP-2和MMP-14的表达对肿瘤的诊断、预后判断、疗效观察起重要作用。 Objective To study the matrix metalloproteinases（matrixmetalloproteinase, MMP - 2 and 14 in the expression and significance of laryngeal cancer. Methods Using flow cytometry detection of 40 cases of laryngeal cancer organizations, 28 cases normal tissue and 15 cases of laryngeal mucosa tissue adjacent to carcinoma in the expression of MMP - 2 and MMP - 14. Results the MMP - 14, MMP - 2 protein expression in the tissue of laryngeal cancer volume were higher than in normal mucosa tissues （P 〈 0.05）. In laryngeal cancer tissues, MMP - 14, MMP - 2 protein and lymph node metastasis, clinical stage, and is closely related to the histologic grading （P 〈 0.05）. Conclusion In laryngeal cancer tissues MMP - 14, high MMP - 2 protein expression may be related to the occurrence of a throat cancer. Joint monitoring of MMP - 2 and MMP - 14 in laryngeal cancer expression of tumor diagnosis, prognosis judgement, curative effect observation plays an important role.
作者 左文娜 吴干勋 李国丽
机构地区 河北省沧州市中心医院耳鼻喉科 河北医科大学第四附属医院耳鼻喉科
出处 《实用临床医药杂志》 CAS 2013年第A01期17-19,共3页 Journal of Clinical Medicine in Practice
关键词 MMP-14 MMP-2 喉癌 临床意义 ： MMP-14 MMP-2 laryngeal cancer clinical significance
分类号 R739.6 [医药卫生—肿瘤]
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参考文献6

  • 1Sounni N E, Baramova E N, Munaut C, et al. Expression of membrane type 1 matrix metalloproteinase(MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization[J]. Int J Cancer, 2002, 98(1): 23.
  • 2张金玲,费雁,陈伟,冯刚.MMP-2、MMP-14、TIMP-2在胃癌组织中的表达及意义[J].华中科技大学学报（医学版）,2013,42(2):227-230. 被引量：25
  • 3Koshikawa, Mizushima H, Minegishi T, et al. Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-lin ovarian carcinoma cells[J]. Cancer Sci, 2011, 102(1): 111.
  • 4Soubani O, Ali A S, Logna F, et al. Re-expression of miR- 200 by novel approaches regulates the expression of PTEN and MTI-MMP in pancreatic cancer[J]. Carcinogenesis, 2012, 33(8): 1563.
  • 5Reis S T, Antunes A A, PontesJ Jr, et al. Underexpression of MMP-2 and its regulators, TIMP2 MT1-MMP and IL-8, is associated with prostate cancer[J]. Int Braz J Urol, 2012, 38(2): 167.
  • 6柳海,李秀,吴强.MMP-2、TIMP-2在口腔鳞状细胞癌中表达的临床病理研究[J].中国肿瘤,2006,15(4):251-254. 被引量：3

二级参考文献22

  • 1Yagasaki H, Kawata N, Takimoto Y, et al. Histopathological analysis of angiogenic factors in renal cell carcionoma [J]. Int J Urol, 2003, 10(4):220-227.
  • 2Zhang X, Yamashita M, Uetsuki H, et al. Angiogenesis in renal cell carcinoma: Evaluation of microvessel density,vascular endothelial growth factor and matrix metalloproteinases[J]. Int J Urol, 2002, 9(9):509-514.
  • 3Munshi HG, Wu YI, Ariztia EV, et al. Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells[J]. J Biol Chem, 2002, 277(44):41480-41488.
  • 4Yorioka CW, Coletta RD, Alves F, et al. Matrix metalloproteinase-2 and-9 activities correlate with the disease-free survival of oral squamous cell carcinoma patients [J].Int J Oncol, 2002, 20(1):189-194.
  • 5Bair EL, Massey CP, Tran NL, et al. Integrin and cadherin mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts [J]. Exp Cell Res,2001, 270(2):259-267.
  • 6Yu J W,Wu J G,Jiang B J,et al. Study on lymph node metas- tasis correlated to lymphangiogenesis, lymphatic vessel inva- sion and lymph node micrometastasis in gastric cancer[J]. J Surg Res,2011,168(2) : 188-196.
  • 7Chen D,Wang Y,Zhang K,et al. Antisense oligonucleotide a- gainst clusterin regulates human hepatocellular carcinoma in- vasion through transcriptional regulation of matrix metallo- proteinase-2 and e-cadherin[J]. Int J Mol Sci, 2012,13 (8): 10594-10607.
  • 8Guo X T, Wang J F, Zhang L Y, et al. Quantitative assess- ment of the effects of MMP-2 polymorphisms on lung carcino- ma risk[J]. Asian Pac J Cancer Prev,2012,13(6):2853-2856.
  • 9Koshikawa N, Mizushima H, Minegishi T, et al. Proteolytic activation of heparin-binding EGF-like growth factor by mem- brane-type matrix metalloproteinase-1 in ovarian carcinoma eells[J]. Cancer Sei,2011,102(1) :111-116.
  • 10Soubani O, Ali A S, Logna F, et al. Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer[J]. Carcinogenesis, 2012,33 (8) : 1563-1571.

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实用临床医药杂志
2013年 第A01期

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