小儿手足口病合并脑炎88例回顾性分析

Retrospective analysis of infantile hand-foot-mouth disease combined with encephalitis

目的总结手足口病合并脑炎患儿的临床特点和治疗经验。方法对88例本院诊治的手足口病合并脑炎患儿的发病年龄、临床表现、辅助检查、治疗方案及临床转归进行回顾性分析。结果手足口病合并脑炎多发生于≤3岁的男性婴幼儿，临床上以皮疹、发热、惊跳、肢体抖动、精神差、嗜睡、呕吐常见，多数外周血、脑脊液白细胞计数升高，免疫功能降低，以EV71感染多见，应早期治疗。结论对手足口病合并脑炎的危重病例，应早期识别，早期治疗，提高治愈率，阻断疾病的进展，减少并发症的发生。

Objective To summary the clinical characteristics and therapeutic experiences of infantile hand-foot-mouth disease combined with encephalitis. Methods Onset ages, clinical manifestations, adjuvant examinations, therapeutic protocols and clinical outcome of 88 infants with hand-foot-mouth disease combined with encephalitis in our hospital were retrospectively analyzed. Results Infantile hand-foot-mouth disease combined with encephalitis often occurred in boys _〈3 years, marked by rash, fever, jumping due to scare, tremble body, poor spirit, preference to sleep as well as vomiting, with increased count of white blood cells in peripheral blood and cerebrospinal fluid and decreased immunological function （mainly EV71）, which should be treated early. Conclusion Severe cases with hand-foot-mouth disease combined with encephalitis should be early diagnosed and treated to improve the cure rate, inhibit disease progression and reduce the complication rate.