原发性肝癌患者血清性激素水平变化及临床意义

Clinical significance and changes of serum sex hormone levels in patients with hepatocellular carcinoma

目的 探讨原发性肝癌患者血清性激素水平的变化及临床意义.方法 采用电化学发光免疫分析法检测健康人群（28例,对照组）,肝硬化患者（28例,肝硬化组）及肝癌患者（28例,肝癌组）血清雌二醇（E2）、睾酮（T）及催乳素（PRL）含量,计算雌二醇/睾酮比值（E2/T）.应用SPSS 13.0统计软件单因素方差分析比较各组间差异.结果 肝癌组E2水平（221.93±11.78） pmol/L、PRL水平（1.48±0.02） nmol/L、E2/T水平（3 889.37 ±14.28）、T水平（0.06±0.08） nmol/L,与对照组的（117.64±5.18） pmol/L、（0.78±0.17）nmol/L、（558.23±11.19）、（0.21 ±0.07） nmol/L差异均有统计学意义（t=17.52、10.73、11.12、14.69,均P＜0.05）.肝癌转移组与肝癌无转移组E2水平与E2/T差异均无统计学意义（均P＞0.05）.结论 性激素水平改变与原发性肝癌的发生过程紧密相关,E2/T增高提示肝癌预后不良.

Objective To explore the changes and clinical significance of sex hormone levels in patients with hepatocellular carcinoma. Methods The serum levels of estrodiol, testosterone, prolactin and E2/T ratio in normal control group（ n = 28 ）, liver cirrhosis patients （ n = 28 ） and hepatocellular carcinoma patients （ n = 28 ） were deter- mined by using chemiluminescente microparticle immunoassay method. All the data collected were calculated by the statistic software SPSS13.0 and ANOVA. Results In hepatocellular carcinoma patients, the serum E2 （221.93 -± 11.78 ） pmol/L, PRL （ 1.48 ± 0.02） nmol/L and E2/T ratio （ 3 889.37 ± 14.28 ） were significantly higher than those of normal control：E2 （117.64 ±5.18） pmol/L,PRL （0.78 ±0.17） nmol/L,EJT （558.23 ± 11.19） ,while serum T level （0.06 ± 0.08 ） nmol/L in hepatoceUular carcinoma patients was significantly lower than that of normal control group （0.21 ± 0.07） nmol/L （t = 17.52,10.73,11.12,14.69, all P 〈 0.05）. The comparison of sex hormone levels and E2/T ratio between metastasis patients and those without metastasis in hepatocellular carcinoma patients had no statistically significant difference （P 〉 0.05 ）. Conclusion Sex hormones levels were related with the hepatocellular carcinoma development. The higher level of serum E/T ratio would indicate poor prognosis.