管状胃重建对食管癌患者呼吸功能和血清血管内皮生长因子水平的影响

Effect of tubular stomach reconstruction on respiratory function and serum VEGF level in patients with esophageal cancer

目的 探讨管状胃重建对食管癌患者呼吸功能和血清VEGF水平的影响.方法 84例食管癌患者随机分为两组,观察组42例和对照组42例,观察组采用管状胃重建消化道,对照组采用全胃代食管重建消化道,观察两组患者治疗前后,术后2个月的呼吸功能,测定患者血清VEGF.结果 手术后两组患者呼吸功能有所下降,与手术前差异均有统计学意义（均P＜0.05）,但两组之间差异无统计学意义（均P＞0.05）;手术后2个月随访,患者的呼吸功能有明显改善,与手术前差异有统计学意义（P ＜0.05,P＜0.01）,并且两组间差异有统计学意义（P＜0.05）.两组治疗后患者血清VEGF均有明显下降（均P＜0.01）,并且观察组降低更明显（P＜0.05）.结论 管状胃重建可以改善食管癌患者的呼吸功能和预后.

Objective To study the effect of tubular stomach reconstruction on respiratory function and serum vascular endothelial growth factor(VEGF) level in patients with esophageal cancer.Methods 84 patients with esophagealcancer were randomIy divided into two groups.42 patients in the observation group were operated through tubular stomach reconstruction,while 42 patients in the control group were operated through full stomach and esophagus reconstruction of digestive tract.The respiratory function and serum VEGF were detected in all patients.Results The respiratory function was significantly declined after operation compared with before operation (P ＜ 0.05).The respiratory function was significantly improved postoperative two months compared with before operation (P ＜ 0.05,P ＜0.01),there was a significant difference between the two groups (P ＜ 0.05).Serum VEGF level was significantly decreased after operation in both two groups (P ＜ 0.0 1).Serum VEGF level of the observation group was significantly lower than that of the control group (P ＜ 0.05).Conclusion Tubular stomach reconstruction can improve respiratory function and prognosis of patients with esophageal cancer.