丙肝核心抗原检测在临床中的应用价值

Clinical value of HCV core antigen detection

目的探讨丙肝核心抗原检测在临床中的应用价值。方法收集300例疑似丙肝病毒感染标本分别检测HCV-Ab、HCV游离核心抗原、HCV总核心抗原、HCV-RNA。结果在82例HCV-Ab阳性反应标本中,检出8例HCV游离核心抗原阳性反应标本,49例HCV总核心抗原阳性反应标本,53例HCV-RNA阳性反应标本;在218例HCVAb阴性反应的标本中,检出1例HCV游离核心抗原阳性反应标本,3例HCV总核心抗原阳性反应标本,3例HCVRNA阳性反应标本。结论 HCV核心抗原检测可以用于HCV病毒感染的早期诊断及疗效观察,也可用于鉴别既往感染或现行感染。

Objective To explore the application value of HCV core antigen detection in laboratory diagnosis of HCV. Methods Three hundred suspected hepatitis C virus infection specimens were collected to detect the HCV - Ab, free HCV core antigen, total HCV core antigen and HCV - RNA. Results In 82 HCV - Ab positive specimens, there were 8 cases with free HCV core antigen positive, 49 cases with total HCV core antigen positive, and 53 cases with HCV -RNA positive; In 218 HCV - Ab negative specimens, there were 1 case with free HCV core antigen positive, 3 cases with total HCV core antigen positive, and 3 cases with HCV - RNA positive. Conclusion HCV core antigen test can be used for early diagnosis and therapeu- tic observation of HCV infection, as well as the differential diagnosis of past infection and current infection.