生物膜耐药机制研究进展

Advanced in Drug Resistance Mechanism of Bio-Membrane

生物膜形成是微生物耐药的重要原因之一,也是许多慢性感染性疾病反复发作和难以治疗的主要原因,微生物生物膜可以通过渗透限制,改变生物膜内外微环境,形成特殊的基因型等多种方式导致耐药。生物膜耐药机制的研究已成为医学、药学、微生物学等众多领域关注的课题。就生物膜耐药机制的最新进展进行综述。

The formation of bio-membrane （BM） is one of the important reasons for microorganisms to resist drugs, it is also the main reason that many chronic infectious diseases break out repeatedly and difficult to treat. In recent years, there are more and more researches on BM drug resistance mechanism. A variety of ways lead to drug resistance of BM, such as limiting penetration, changing the biofilm internal and external environment and forming a special genotype, etc. The research of BM drug resistance mechanism has become a topic in medicine, pharmacy, microbiology and many other fields. The latest progress in the BM drug resistance mechanism is summarized in this paper.