天然辅助细胞及其对相关疾病影响的研究进展

Advanced in Natural Helper Cells and Its Effects on Related Diseases

天然辅助细胞(natural helper cell,NHC)是一种近期发现于鼠体内的2型固有淋巴细胞(innate lymphoid cells,ILCs2)。NHC起源于骨髓淋巴系祖细胞,由iNH细胞分化而来,且处于分化终末阶段。这些细胞主要位于腹腔内的脂肪相关淋巴簇(fat-associated lymphoid cluster,FALC)与肺组织中,在其形态及特征方面,与淋巴细胞具有相似性。其表面高度表达-kit、sca-1、IL-7R,而缺乏lineage标记。经过不同刺激信号的作用,NHC可产生相应的Th2型细胞因子,如IL-5、IL-6与IL-13,进而调节IgA抗体的产生并辅助B1细胞自我更新。NHC分泌的大量IL-5和IL-13可促进嗜酸性粒细胞与杯状细胞的增生,同时促进黏液分泌,参与过敏反应及呼吸道炎症的发生并在抵抗寄生虫感染的过程中发挥关键作用。

Nature helper cells （NHC） are recently discovered in rats with type 2 innate lymphocytes （ILCs2）. NHC originated in the bone marrow lymphoid progenitor cells, were differentiated from iNH cells, and were in the final stage of differentiation. These cells were mainly located in the fat associated lymphoid clusters intraperitoneal fat-asso- ciated lymphoid cluster （FALC） and lung tissues, in terms of their shape and characteristics, they have the similarity with lymphocytes. Their surfaces highly express-kit, sca-1, IL-7R, but lack of lineage markers. After the action of different simulative signals, NHC can produce corresponding Th2 type cytokines such as IL-5, IL-6, and IL-13, then adjust to produce IgA antibodies and help B1 cell to self-renew. A large number of IL-5 and IL-13 secretion of NHC can promote hyperplasia of eosinophilic granulocytes and goblet cells, and promote the secretion of mucus, participate in allergic reactions and respiratory tract inflammation and play a key role in the process to resist parasitic infection.