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骨髓间充质干细胞治疗缺血性脑卒中研究进展 被引量：7

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摘要 缺血性脑卒中是由于各种原因所致的脑部血液供应障碍，导致脑组织缺血、缺氧性坏死，出现的相应神经功能缺损。神经元的可塑性和神经环路的重建在某种程度上可促进其功能的恢复，但大多数患者仍会遗留持续性的运动、感觉和认知功能上的障碍。
作者 王苏平 孙鑫 李深
机构地区 大连市中心医院神经内科
出处 《中风与神经疾病杂志》 CSCD 北大核心 2014年第3期280-282,共3页 Journal of Apoplexy and Nervous Diseases
关键词 缺血性脑卒中 干细胞治疗 骨髓间充质 血液供应障碍 神经功能缺损 脑组织缺血 神经环路 认知功能
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献33

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  • 3Blondheim NR, Levy YS, Ben-Zur T, et al. Human mesenchymal stem cells express neural genes, suggesting a neural predisposition[J] . Stem Cells and Development, 2006 , 15 ( 2) : 141 - 164.
  • 4Wakabayashi K,Nagai A, Sheikh A M,et al. Transplantation of hu?man mesenchymal stem cells promotes functional improvement and in?creased expression of neurotrophic factors in a rat focal cerebral ische?mia model[J].Journal of Neuroscience Research ,2010 ,88 (5) : 1017 - 1025.
  • 5Xin H, Li Y, Shen L H, et al. Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAl-I expression in astrocytes through the sonic hedgehog signaling pathway after stroke ( in vitro study)[J].Journal of Cerehral Blood Flow & Metabolism, 20 II ,31 ( II ) : 2181 - 2188.
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  • 7Zyuz' kov GN , Suslov NI, Dygai AM, et al. Role of stem cells in adap?tation to hypoxia and mechanisms of neuroprotective effect of granulo?cytic colony-stimulating factor[J]. Bulletin of Experimental Biology and Medicine ,2005, 140( 5) :606 - 611.
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二级参考文献33

  • 1莫纪华,郑秀珏,杨小锋.大鼠严重脑损伤后细胞凋亡状态及相关基因Bcl-2、Bax的表达[J].中华创伤杂志,2004,20(7):432-433. 被引量：12
  • 2庄淑波,刘毅,陈克明,肖斌.大鼠骨髓间充质干细胞体外分离、纯化与培养适宜条件的筛选[J].中国组织工程研究与临床康复,2007,11(20):3886-3891. 被引量：26
  • 3中华人民共和国科学技术部.关于善待实验动物的指导性意见.2006.09-30
  • 4Li TS,Komota T,Ohshima M,et al.TGF-beta induces the differentiation of bone marrow stem cells into immature cardiomyocytes.Biochem Biophys Res Commun.2008;366(4):1074-1080.
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  • 9Li LY,Li JT,Wu QY,et al.Transplantation of NGF-gene-modified bone marrow stromal cells into a rat model of Alzheimer' disease.J Mol Neurosci.2008;34(2):157-163.
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共引文献9

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二级引证文献14

中风与神经疾病杂志
2014年 第3期

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