高血压患者视觉非随意注意的事件相关电位研究

Study of event-related potential visual involuntary attentive in patients with hypertension

目的：探讨高血压患者视觉非随意注意的特点。方法：采用事件相关电位（ERP）成分P3a，对12例原发性高血压患者和12例正常对照者的视觉非随意注意进行客观评价，并对所有被试者采用简易智能精神状态检查量表（MMSE）进行认知功能测评。结果：与正常对照组相比，高血压患者的MMSE评分明显降低（P〈o．05）。N2波幅显著降低（P〈0．05），其中以额一中央区下降更明显（P〈0．05）。正常对照组，N2波幅以Fz、Cz分布为明显（P％0．05），而高血压却以Pz最大（P〈O．05）；N2潜伏期两组间差异不明显（P〉0．05）；高血压组较正常对照组P3a波幅降低，但差异无统计学意义（P〉0．05）；高血压组的P3a潜伏期较正常对照组明显延长，差异有统计学意义（P〈0．05）。结论：高血压患者存在视觉非随意注意加工障碍，注意ERP检测对研究高血压患者的发病机制及评定提供了新的客观证据。

Objective：To investigate the characteristics of involuntary attention in patients with hy- pertension. Methods： P3a component of the event related potentials（ERP）was used to value visual invol- untary attention of 12 patients with essential hypertension and 12 norrmal controls. All the subjects were submitted to cognitive assessment by Mini-Mental-State-Examination（MMSE）. Results： Compared with control group, the MMSE score of patients with hypertension was decreased（P〈0.05）. The mean ampli- tude of N2 in hypertensive patients decreased more obviously than normal controls（P〈0.05）, particularly at forehead central sites（P〈0. 05） , whereas the N2 component was larger at forehead-central region in controls（P〈0.05）. But for the latency of N2,there was no significant effect of both groups. In addition, the latency of P3a of hypertensive patients was different from normal controls, but there was no statistical significance（P〈0.05）. The latency of visual P3a was significantly longer in patients with hypertension than in controls（P〈0.05）. Conclusion：The problem in the processing of visual involuntary attention oc- curs in hypertensive patients,and the study of it provides new objective evidence for the mechanism and assessment of visual involuntary attention in patients with hypertension.