血清GnSAF水平与多囊卵巢综合征的相关性研究

Study on the correlation between serum GnSAF level and polycystic ovary syndrome

目的:检测多囊卵巢综合征(PCOS)患者血清GnSAF水平,探讨其在PCOS发病的意义。方法 :选取61名PCOS患者及64名对照者,计算体重指数(BMI)及腰臀比(WHR),采用电化学发光法测定生殖性激素,包括卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、催乳素(PRL)、睾酮(T),采用酶联免疫吸附法测定血清GnSAF水平。结果:两组间年龄及WHR均无统计学意义;BMI比较差异有统计学意义;PCOS组GnSAF血清浓度高于对照组,但差异没有统计学意义;除E2与GnSAF呈负相关,有统计学意义外,其余各指标与GnSAF均无相关性。结论:PCOS患者血清GnSAF水平升高,可能与PCOS发病、卵泡发育障碍有关。

Objective： To detect the serum level of gonadotrophin surge attenuating factor （GnSAF） in patients with polycystic o- vary syndrome （ PCOS ） , explore its significance in occurrence of PCOS. Methods： Sixty - one PCOS patients were selected as PCOS group, 64 normal women were selected as control group; body mass index （BMI） and waist hip ratio （WHR） were calculated; electrochemiluminescence was used to detect levels of sexual hormones, including follicle - stimulating hormone （FSH） , luteinizing hormone （ LH ）, estradiol, prolaetin （PRL）, testosterone （T） ; ELISA was used to detect, serum level of GnSAF. Results： There was no Statistically significant difference in age and WHR between the two groups; there was statistically significant difference in BMI between the two groups; the serum level of GnSAF in PCOS group was higher than that in control group, but there was no statistically significant difference ; there was a negative correlation between estradiol and GnSAF, while there was no correlation between GnSAF and the other indexes. Conclusion： The increase of serum GnSAF level in PCOS patients is correlated with occurrence of PCOS and follicular developmental disorder.