妊娠期血栓弹力图各项指标变化趋势

The changes of thrombelastography in normal pregnant women during different periods of pregnancy

目的探讨正常妊娠不同时期血栓弹力图（thrombelastographyTEG）各项指标的变化趋势。方法选择2011年12月至2013年1月在中国医科大学附属盛京医院产科进行产检的孕妇73例为研究对象。其中早期妊娠（12“周）19例（早孕组），中期妊娠（13～27“周）21例（中孕组），晚期妊娠（28～40周）33例（晚孕组）。另选同时期我院健康体检的未孕育龄女性10例作为对照组（非孕组）。对上述病例进行TEG检测，统计分析TEG5项指标（K值、R值、Angle角、MA值、CI值）的变化。结果K值，孕妇组为（2．03±0．57）min，较非孕组（2．49±0．76）min明显缩短（P〈0．05），并且随孕周增加K值逐渐降低（P〈0．05）。Angle角孕妇组为（62．77±6．00）°，较非孕组（57．61±7．62）。明显升高，并随孕周增加逐渐升高（P〈0．05）。MA值和cI值孕妇组较非孕组明显增大（P〈0．05），但不同孕周间差异无统计学意义。R值各纽间差异均无统计学意义。结论孕妇较非孕妇TEG多项指标存在明显差异，妊娠不同时期TEG各项指标存在相应的变化。TEG是妊娠妇女凝血功能监测方法之一．

Objective To evaluate the thrombelastography （TEG） values changes of normal pregnant women in different periods of pregnancy. Methods Selected 73 cases of pregnant women and 10 cases of non-pregnant women, in which there are 19 cases of women in early pregnancy, 2l cases of mid-pregnant women and 33 cases of women in late pregnan- cy for TEG testing to detect changes of TEG values, including K,R,Angle ,MA and CI values. Results K values of preg- nant women were （2.03±0.57 ）min ,those were significantly shorter than non-pregnant women（2.49 ± 0.76 ）min, With the growth of gestational age, K values became shorter gradually （ P 〈 0. 05 ）. Angel values of pregnant women were （62. 77 ± 6. 00）°, those were significantly increased than non-pregnant women （57.61 ± 7. 62 ）o, With the growth of ges- rational age, Angel values increased significantly （P 〈 0. 05 ）. MA values and CI index of pregnant women were signifi- cantly increased than non-pregnant women（ P 〈0. 05 ）, but there is no significant differences among different periods of pregnancy. R values showed no significant differences （ P 〉 0. 05 ）. Conclusion Many values of TEG showed significant differences between pregnant women and non-pregnant women, Some values of TEG showed significant differences among different periods of pregnancy. TEG is one of useful indicators to evaluate the coagulation changes of pregnant women.