股骨头坏死愈胶囊对兔激素性股骨头坏死血清骨钙素与降钙素的影响

Impacts on Steroid-Induced Femoral Head Necrosis,Serum Osteocalcin and Calcitonin Treated with Gugutou Huaisi Yu Capsules in Rabbits

目的探讨股骨头坏死愈胶囊对激素性股骨头坏死的防治效果及作用机制,为该药的临床应用提供科学依据。方法以36只新西兰大白兔为研究对象,随机分为正常组和股骨头坏死愈组、通络生骨胶囊组、造模空白组,通过血液学检查统计各组血清中骨钙素及降钙素水平。结果通过光镜观察结合X线电子计算机断层扫描(CT)和核磁共振扫描(MRI)检查证明造模成功,治疗后,造模组血清BGP与CT水平明显低于正常组(P<0.05);给药12周时测量结果显示股骨头坏死愈组血清BGP与CT水平明显高于模型组(P<0.05);通络生骨胶囊组血清BGP与CT水平明显高于模型组(P<0.05);股骨头坏死愈组血清BGP与CT水平与通络生骨胶囊组相比,各个指标差异均无统计学意义(P>0.05)。结论股骨头坏死愈胶囊能够提高兔激素性股骨头坏死血清骨钙素与降钙素水平,对激素性股骨头坏死具有治疗作用。

Objective To explore the preventive effect and mechanism on steroid-induced femoral head necrosis treated with Gugutou Huaisi Yu Capsules so as to provide the scientific evidence of the drug for clinical application.Methods Thirty-six New Zealand white rabbits were selected as the subjects and ran-domized into a normal group,Gugutou Huaisi Yu Capsules group,Tongluo Shenggu Capsules group and model blank group.The levels of serum osteocalcin and calcitonin were analyzed statistically with hematologic exam-ination.Results The optical microscope,X-ray CT and MRI were used together to prove the success of modeling.After treatment,the levels of osteocalcin and calcitonin in the model group were lower apparently than those in the normal group（P〈0.05）.In 1 2 weeks of medication,the levels of osteocalcin and calcitonin in Gugutou Huaisi Yu Capsules group were higher apparently than those in the model group（P〈0.05）, Those in Tongluo Shenggu Capsules were higher apparently than those in the model group（P〈0.05 ）.The difference was not significant in comparison between Gugutou Huaisi Yu Capsules group and Tongluo Shenggu Capsules（P〉0.05）.Conclusion Gugutou Huaisi Yu Capsules increase the levels of osteocalcin and calci-tonin in rabbits and are effective in the treatment of steroid-induced femoral head necrosis.