调控Muller细胞去分化为视网膜前体细胞的信号通路

The signaling pathways regulating Muller cells to dedifferentiate into the retinal progenitor cells

在视网膜中,Muller细胞被视为具有干细胞特性及再生修复能力,刺激内源性干细胞活化增殖并向视网膜前体细胞去分化,或许是治疗视网膜疾病的重要策略之一。然而,在高等哺乳动物视网膜中,Muller细胞自发去分化的能力极为有限。近年来研究发现,某些生长因子、转录因子及细胞外基质能通过一系列信号通路促进视网膜Muller细胞的去分化及再生修复。阐明这些信号通路的调控机制将对利用内源性干细胞治疗视网膜疾病有极大的帮助。

In the retina, Muller cells are considered to have stem cell properties and regenerative ability. Stimulating the endogenous stem cells to proliferate and dedifferentiate into retinal progenitor cells may be one of the important strategies for the treatment of retinal diseases. In the retina of higher mammals, however, the spontaneous dedifferentiation ability of Muller cells is very limited. In recent years, studies have found that some growth factors, transcription factors, extracellular matrix can promote the dedifferentiation and regeneration ability of Muller cells through a series of signaling pathways. Ascertaining these regulatory mechanisms of signaling pathways will be a great help to utilize the endogenous stem cells to treat retinal diseases.