真核翻译起始因子5A和多胺代谢及肿瘤的关系

Relationship between eukaryotic translation initiation factor 5A,polyamine metabolism and tumor

真核翻译起始因子5A(eIF5A)是真核生物中普遍存在且高度保守的蛋白质,含有一个独特的氨基酸——羟腐胺赖氨酸,该氨基酸是在赖氨酸的基础上经翻译后修饰而成,该过程与多胺代谢密切相关。研究发现,eIF5A和多胺代谢以及肿瘤的发生发展密切相关,有望成为抗肿瘤靶向治疗新的分子靶点。现就eIF5A和多胺代谢及肿瘤关系的研究进展作一简要综述。

Eukaryotic translation initiation factor 5A （eIF5A） is a ubiquitous and highly conserved protein in eukaryotes, containing a unique amino acid： hypusine. Hypusine comes from lysine residue by post-translation modification and this process is closely related to the polyamine metabolism. Recent studies found that eIF5A and polyamine are closely related to tumorigenesis and development. It is expected to become a new target for tumor therapy. This paper briefly reviews the relationship between eIF5A, polyamine metabolism and tumor.