星点设计效应面法优选鱼腥草分散片的处方工艺

Optimization of the Formulation Technology of Houttuynia cordata Dispersible Tablets by Central Composite Design and Response Surface Method

目的：优选鱼腥草分散片的处方工艺。方法：以交联聚维酮（PVPP）、交联羧甲基纤维素钠（CCNa）、羧甲基淀粉钠（CMS）用量为考察因素，以崩解时限和累积溶出度为评价指标，采用星点设计效应面法优选鱼腥草分散片的处方工艺。结果：最优处方工艺为PVPP用量为19-20mg，CCNa用量为29-37mg，CMS用量为21-27mg。结论：优选的处方工艺稳定、可行，可用于制备鱼腥草分散片。

OBJECTIVE： To optimize the formulation technology of Houttuynia cordata dispersible tablets. METHODS： The formulation technology of H. cordata dispersible tablets was optimized by central composite design and response surface method with the amount of PVPP, CCNa and CMS as factors, using disintegration time and cumulative dissolution as index. RESULTS： The optimal formulation technology was as follows： PVPP 19-20 mg, CCNa 29-37 mg, CMS 21-27 rag. CONCLUSIONS： The opti- mal technology is stable and feasible, which can be used for the preparation of H. cordata dispersible tablets.