天麻素治疗伴精神心理障碍老年人功能性消化不良的疗效观察

Efficacy Observation of Gastrodin in the Treatment of Senile Functional Dyspepsia Complicating with Psychological Disorder

目的:观察天麻素治疗伴精神心理障碍老年人功能性消化不良(SFD)的临床疗效。方法:选择58例伴精神心理障碍的SFD确诊病例,按随机数字表法均分为治疗组和对照组。对照组给予口服奥美拉唑胶囊20 mg,每日1次+多潘立酮片10 mg,每日3次;治疗组在对照组基础上加用天麻素注射液0.6 g静脉滴注,每日1次。两组疗程均为10 d。观察两组患者治疗后消化不良症状总疗效、积分变化与焦虑抑郁量表评分变化。结果:对照组和治疗组消化不良症状总有效率(分别为58.6%和82.8%)和不良症状(恶心、嗳气等)积分,组间比较差异有统计学意义(P<0.05)。治疗组焦虑、抑郁等精神心理障碍症状自评量表-90、抑郁自评量表及焦虑自评量表评分较治疗前明显降低(P<0.01),且低于对照组,差异有统计学意义(P<0.05)。结论:天麻素对伴精神心理障碍的SFD具有较好治疗效果。

OBJECTIVE： To observe clinical efficacy of gastrodin in the treatment of senile functional dyspepsia （SFD） compli- cating with psychological disorder. METHODS： 58 SFD patients with psychological disorder were randomly divided into treatment group and control groups with 29 cases in each group. Control group was given Omeprazole capsules 20 mg once a day and Dom- peridone tablets 10 mg 3 times a day; treatment group was given Gastrodin injection 0.6 g intravenously once a day for consecutive 10 days, on the basis of control group. Efficacy of dyspepsia, the changes of score and anxiety scale were observed in 2 groups af- ter treatment. RESULTS： The total effective rates of treatment group and control group were 58.6% and 82.8% respectively, and symptom （nausea and belching） score were evaluated in 2 groups; there was statistical significance （P〈0.05）. The scores of SCL-90, SDS and SAS of mental disorders as anxiety and depression decreased significantly in treatment group after treatment（P〈 0.01 ）; those were lower than in control group （P〈0.05）. CONCLUSIONS： Gastrodin have sound therapeutic efficacy in the treat- ment of SFD complicating with psychological disorder.