中国人群对氧磷酯酶1基因Q192R多态性与冠心病关联性的Meta分析

Association between the paraoxonase-1 Q192R polymorphism and coronary heart disease in Chinese population： A Meta-analysis

目的 探讨中国人群对氧磷酯酶1（PONl）基因Q192R多态性与冠心病的相关性.方法 全面检索关于PON1基因Q192R多态性与冠心病关联性的原始研究,纳入符合入选标准研究,并进行数据合并.利用PON1基因的不同遗传模型OR值及其95％CI作为效应指标进行分析.结果 16个原始研究共计5701例对象（其中冠心病患者2905例,健康对照2796例）进入最后的数据合并.Meta分析表明,PONl基因Q192R多态性与冠心病易感性无相关性[纯合子比较模型（RR比QQ）：OR =0.80,95％CI 0.57～1.11,P=-0.19;杂合子比较模型（QR比QQ）：OR =0.89,95％CI 0.75～1.07,P=0.21;显性遗传模型（RR＋QR比QQ）：OR=0.87,95％CI 0.72～1.06,P=0.18;隐性遗传模型（RR比QR＋QQ）：OR =0.87,95％CI 0.67～1.13,P=0.31].结论 中国人群冠心病易感性与PON1基因Q192R多态性无关.

Objective To investigate the associations between the paraoxonase-1 Q192R polymorphism and coronary heart disease in Chinese population.Methods Data bases were comprehensively searched,together with references retracing method,for all the related studies on the associations between the paraoxonase-1 Q192R polymorphism and type 2 diabetes.All the related studies were further strctly selected according to the inclusion criteria.The pooled odds ratios （OR） with 95％ confidence intervals （95％CI） of the association between paraoxonase-1 Q192R polymorphism and susceptibility to coronary heart disease were performed in different genetic model comparison.Results 16 original studies with a total of 5701 subjects （CHD 2905 patients and 2796 controls）were entered the final data combination.The results of meta-analyses showed no significant difference was found in the associations between paranxonase-1 Q192R polymorphism and coronary heart disease risks in different genetic model comparison[（RR vs QQ）：OR=0.80,95％CI 0.57-1.11,P=0.19,（QR vs QQ）：OR=0.89,95％CI 0.75-1.07,P=0.21,（RR＋QR vs QQ）：OR=0.87,95％CI 0.72-1.06,P=0.18,（RR vs QR＋QQ）：OR=0.87,95％CI 0.67-1.13,P=0.31].Conclusion Meta-analysis strongly suggests that there are no significant associations between coronary heart disease susceptibility and paraoxonase-1 Q192R polymorphism in Chinese population.