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内皮型一氧化氮合酶基因多态性与冠心病的研究进展 被引量：1

Endothelial nitric oxide synthase gene polymorphism and coronary heart disease
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摘要 冠状动脉粥样硬化性心脏病（cronary atherosclerotic heart disease,CHD）简称冠心病,是指冠状动脉发生粥样硬化引起管腔狭窄或闭塞,导致心肌缺血缺氧或坏死引起的心脏病.吸烟、肥胖、高血压及代谢综合征等均已成为广为人知的几个冠心病重要危险因素.但也有患者没有这些危险因素存在,并且在一些个体中,常有明显的冠心病家族史,说明冠心病是环境与遗传危险因素动态相互作用所致的.目前已有诸多冠心病基因多态性研究,包括内皮型一氧化氮合酶（endothelial nitric oxide synthase,eNOS）.在近年的荟萃分析中显示,某些遗传变异可能为特定群体冠心病发病的危险因素之一.
作者 朴丽梅(综述) 李玉子(审校)
机构地区 延边大学附属医院心内科
出处 《中国心血管病研究》 CAS 2014年第3期261-265,共5页 Chinese Journal of Cardiovascular Research
关键词 内皮型一氧化氮合酶 基因多态性 冠状动脉疾病 Endothelial nitric oxide synthase Gene polymorphoism Coronary heart disease
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献29

  • 1Yeshirmura M, Yasue H, Nskaymm M, et al. A missense Glu29SAsp variant in the endothelial nitric oxide synthase with coronary spasm in the Japanese. Hum Genet, 1998,103:65-69.
  • 2Chang K, Baek SH, Seung KB, et al. The Glu298Asp polyrnor-phism in the endothelial nitric oxide synthase gene is strongly as- sociated with coronary spasm. Coron Artery Dis,2003,14:293- 299.
  • 3Patemoster L, Martinez-Gonzalez NA, Charleton R, et al. Ge- netic effects on carotid intima-media thickness: Systematic as- sessment and meta-analyses of candidate gene polymorphisms studied in more than 5000 subjeets. Cire Cardiovasc Genet, 2010,3 : 15-21.
  • 4Salimi S, Firoozrai M, Zand H, et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism in patients with coronary artery disease. Annals of Saudi Med, 2010,30 : 33-37.
  • 5Abdel-Aziz TA, Mohamed RH. The association of smoking, obe- sity, dyslipidemia and/or metabolic syndrome with the TT geno- type increased the risk of the development of PCAD. Mol Biol Rep, 2013,40 : 3065-3071.
  • 6Min BW, Na JY, Juhng SW, et al. Genetic effects on carotid intima-media thickness: Systematic assessment and meta-A polymorphism (G894T) in eNOS increases the risk of coronary atherosclerosis rather than intracranial atherosclerosis in Koreans. Acta Neurol Belg, 2010, 110 : 255-262.
  • 7Li J, Wu X, Li X, et al. The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis. Cardlology, 2010,116: 271-278.
  • 8Tian GX, Zeng XT, Wang XB. Association between the endothe- lial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta analysis of 39 case control studies. Mol Med Rep,2013,7:1310-1318.
  • 9Rahimi Z, Nourozi-Rad R. Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran. Angiology, 2012,63 : 131-137.
  • 10Alkharfy KM, A1-Daghri NM, A1-Attas OS, et al. Endothelial nitric oxide synthase gene polymorphisms (894G>T and-786T> C) and risk of coronary artery disease in a Saudi population. Arch Med Res,2010,41: 134-141.

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中国心血管病研究
2014年 第3期

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