HIV/AIDS病人中甲型H1N1流行性感冒感染情况

The situation of H1N1 Influenza in HIV/AIDS patients

目的了解艾滋病病毒（HIV）感染者／艾滋病（AIDS）病人（HIV／AIDS病人）中，甲型H1N1流行性感冒（流感）感染状况，分析研究HIV／AIDS病人的CD4^＋T淋巴细胞（简称CD4细胞）水平，对甲型H1N1流感病毒抗体水平的影响，为评价甲型H1N1流感、HIV／AIDS病人现有防控策略和措施提供技术支持。方法对252例HIV／AIDS病人进行问卷调查，并采集静脉血2～5mL检测流感抗体。对问卷调查结果及实验室检测结果以Excel为基础建立数据库，应用SPSS17．0软件对资料进行分析。结果252例HIV／AIDS病人中，甲型H1N1流感抗体阳性40例，阳性率15．9％，阴性212例（84．1％）。流感抗体阳性与阴性者比较显示，CD4细胞水平、有无接种甲型流感疫苗的差异有统计学意义，年龄、性别、婚姻状况、教育程度等情况差异无统计学意义。HIV／AIDS病人与健康人群甲型H1NI流感的抗体阳性率差异有统计学意义。结论HIV／AIDS病人因免疫力低下可优先考虑接种流感疫苗。低CD。细胞水平是感染甲型H1N1流感的危险因素。

Objective To understand situation of H1N1 influenza in HIV/AIDS patients and explore the impact of CD4 ＋T cells on HIN1 influenza virus antibodies to provide technical support for evaluation and control of H1N1 influenza. Methods Questionnaire survey was conducted in 252 HIV/AIDS patients and 2--5 ml venous blood was collected to measure CD4 ＋T cell counts and H1N1 antibodies. Excel based database were created using the results of survey and laboratory tests, and analyzed by SPSS 17.0. Results The positive rate of H1N] antibody in HIV/ AIDS patients was 15.9% （40/252）, which had no differences compared with that in health control. There were significant differences in CD4 cell counts and influenza vaccine inoculation, but no significant differences in age, gen- der, marital status, education level and so on between H1N1 influenza antibody positive individuals and negative ones. Conclusion Vaccination should be considered in HIV/AIDS patients due to compromised immunity. CD4 ＋ T cell？ count is a risk factor for infection of H1N1 influenza virus.