颈动脉内-中膜厚度与冠状动脉病变程度的相关性研究

Relevant research between internal-media thickness of arteria cervicalis and the degree of the coronary artery lesions

目的探讨颈动脉内-中膜厚度（IMT）与冠状动脉病变程度的相关性。方法选取本院自2012年1月-2013年1月收治的136例经冠状动脉造影证实为冠心病的患者为研究对象（冠心病组。n=136），并按照病变程度分为单支病变组（n=38）、双支病变组（n=52）和多支病变组（n=46），选取同期冠脉造影正常的100例患者为对照组（非冠心病组，n=100）。所有患者均行双侧颈动脉超声检查，记录颈动脉IMT、斑块Crouse积分以及冠状动脉Gemini积分，分析各指标间的相关性。结果冠心病组IMT[（5．12±3．73）mmVS（1．14±0．22）mm]、斑块Crouse积分[（1．27±0．34）分VS（0．75±0．16）分]以及冠状动脉Gensini积多[（21．82±9．25）分Vs（0．00±O．00）分]均明显高于非冠心病组，差异均有统计学意义（均P〈0．05）；多支病变组颈动脉IMT、斑块Crouse积分以及冠状动脉Gensini积分均明显高于单支病变组和双支病变组，差异均有统计学意义（均P〈0．05）；相关性分析显示冠状动脉Gensini积分与IMT（r=0．76）和斑块Crouse积分（r=0．66）均呈正相关，差异均有统计学意义（均P〈0．05）。结论颈动脉内-中膜厚度与冠状动脉病变程度高度相关，及时进行颈动脉超声检查可以早期发现冠状动脉病变。

Objective To investigate the relevant research between internal-media thickness （IMT） of arteria cervicalis and the degree of the coronary artery lesions. Methods 136 patients with coronary heart disease confirmed by coronary angiography （coronary heart disease group, n=136） admitted at our hospital from January 2012 to January 2013 were divided into the single-vessel disease group（n=38）, double branch lesion group （n=52） and multiple vessel disease group（n=46）.100 cases of healthy patients were selected to be as the control group （non-coronary heart disease group, n=136）.A]l patients were performed bilateral carotid ultrasound to record carotid IMT and plaque Crouse integral and coronary artery Gensini scores and the correlation between indicators were analyzed. Results The IMT [ （5.12±3.73）mm VS（1.14±0.22）mm ] , plaque Crouse integral [ （1.27±0.34） score VS（0.75±0. 16）score ] and coronary artery Gensini scores [ （21.82±9.25）score VS（0.00±0.00）score ] of the multiple vessel disease group were apparently higher than the non-coronary heart disease group,the differences were statistically significant（all P〈O.05）.The IMT, plaque Crouse integral and coronary artery Gensini scores of the coronary heart disease group were apparently higher than the single-vessel disease group group and double branch lesion group,the differences were statistically significant（all P〈0.05）.Correlation analysis showed that there was a positive correlation for the coronary artery Gensini scores between IMT （r=-0.76）and Crouse integral（r=0.66）,the differences were statistically significant（all P〈0.05）. Conclusion The internal-media thickness of arteria cervicalis is highly associated with the degree of coronary artery lesions, a timely manner carotid ultrasound examination can early detect the coronary artery lesions earlier.