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伊立替康单药二线治疗进展期结直肠癌的临床价值分析

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摘要 目的分析研究伊立替康单药二线治疗进展期结直肠癌的临床价值。方法盲选本院收治的66例进展期结直肠癌患者,给予患者采用伊立替康单药二线治疗,分析评价其临床价值。结果 66例患者治疗后,部分缓解16例(24.2%),稳定34例(51.6%),进展16例(24.2%),有效率为24.2%,疾病控制率为75.8%。血液学毒性为Ⅰ度骨髓抑制以及Ⅱ度中性粒细胞减少症38例(57.6%),Ⅲ+Ⅳ度中性粒细胞减少症24例(36.4%);非血液学毒性为:Ⅰ+Ⅱ度恶心呕吐38例(57.6%),Ⅲ+Ⅳ度恶心呕吐5例(7.6%),Ⅰ+Ⅱ度迟发性腹泻24例(36.4%),Ⅲ+Ⅳ度迟发性腹泻4例(6.1%)。结论给予进展期结直肠癌患者采用伊立替康单药二线治疗,疗效满意,安全可靠,值得应用推广。
作者 陈飞
出处 《中国实用医药》 2014年第5期153-154,共2页 China Practical Medicine
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  • 1郁宝铭,吴唯勤.伊立替康与氟嘧啶类联合治疗进展期及转移性结直肠癌的临床研究[J].中华外科杂志,2005,43(9):557-560. 被引量:5
  • 2Grothey A, Sargent D, Goldberg RM, et al. Survival of patients with advanced colorectal cancer improves with the availability of flu- orouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol, 2004, 22(7) :1209-14.
  • 3Jain RK. Normalization of tumor vaseulature : An emerging concept in antiangiogenic therapy. Science, 2005, 307 (5706) :58-62.
  • 4Cunningham D, Humblet Y, Siena S,et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med, 2004, 351(4) :337-45.
  • 5Hanahan D, Bergers G, Bergsland E. Less is more, regularly: met- ronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest, 2000,105(8) :1045-7.
  • 6Colleoni M, Rocca A, Sandri MT, et al. Low-dose oral methotrex- ate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor lev- els. Ann Oncol, 2002,13 ( 1 ) :73-80.
  • 7GhiringheUi F, Menard C, Puig PE, et al. Metronomic cyclophos- phamide regimen selectively depletes CIM + CD25 + regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunot Immunother, 2007,56(5 ) :641-8.
  • 8Ooyama A, Oka T, Zhao H, et al. Anti-angiogenic effect of 5-Flu- orouracil-based drugs against human colon cancer xenogrufts. Canc- er Lett, 2008,267( 1 ) :26-36.
  • 9侯中博,肖天宝.结直肠癌研究进展[A].贵州省中西医结合学会、贵州省肛肠病医院.贵州省中西医结合学会肛肠学会第五届学术交流会暨新技术新进展学习班论文汇编[C].贵州省中西医结合学会、贵州省肛肠病医院,2012:6.11-12.
  • 10Fuchs CS, Marshall J, Mitchell E ,et d.Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer:results from the BICC-C Study[J].J Clin 0ncol,2007,25(30) :4779-4786.

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