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溃疡性结肠炎患者血清25(OH)维生素D水平与疾病活动性的相关性 被引量:9

Association of serum 25 (OH) vitamin D levels with ulcerative colitis activity
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摘要 目的检测溃疡性结肠炎患者血清25(OH)维生素D水平,并分析25(OH)维生素D水平与疾病活动性的关系,探讨其临床意义。方法选择40例溃疡性结肠炎患者和30例健康对照者为研究对象,采用ELISA法检测溃疡性结肠炎患者和健康体检者血清中25(OH)维生素D水平,应用Mayo评分法对UC病人的疾病活动度进行分级,将维生素D水平与UC患者临床资料以及疾病活动度进行相关性分析。结果溃疡性结肠炎患者血清25(OH)维生素D水平(15.8±12.3)ng/ml明显低于健康对照组(42.5±26.7)ng/ml,p<0.05,血清25(OH)维生素D水平与患者年龄、性别、病程、是否吸烟、抗生素的应用、5-氨基水杨酸的应用及非甾体类抗炎药的应用无相关性,但与皮质类固醇激素的应用及溃疡性结肠炎的活动性相关。结论溃疡性结肠炎患者低储备维生素D水平与疾病活动性及皮质类固醇激素的应用相关。 Objective To determine serum 25(0H) vitamin D levels in patients with ulcerative colitis(UC) and analyze the association of serum 25(OH) vitamin D concentrations with disease activity. Methods A total of 40 ulcerative colitis patients and 30 healthy controls were enrolled in the study, 25(0H) vitamin D serum concentrations were measured by ELISA kit, clinical disease activity was calculated using the Mayo index, the relationship of vitamin D levels with clinical data and clinical disease activity was analyzed. Results Serum Vitamin D levels were found to be lower in patients with ulcerative colitis(15.8 ± 12.3)ng/ml than in healthy controls(42.5± 26.7)ng/ml, (P 〈0.05), but not related significantly to patients age, gender, average duration of UC diagnosis, current medication antibiotics NSAIDs and 5-ASA, however, related significantly to the medication of Steroids and disease activity. Conclusion Vitamin D deficiency in patients with active ulcerative colitis is related to the medication of Steroids and disease activity.
出处 《解剖科学进展》 CAS 2014年第2期142-144,150,共4页 Progress of Anatomical Sciences
基金 沈阳市科学技术基金项目(F13-318-1-42)
关键词 维生素D 人溃疡性结肠炎 炎症性肠病 Vitamin D human ulcerative colitis inflammatory bowel disease
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参考文献15

  • 1Ananthakrishnan AN. Environmental triggers for inflammatory bowel disease[J]. Curt Gastroenterol Rep, 2013, 15(1): 302.
  • 2Holiek MF. Vitamin D deficiency[J]. N Engl J Med, 2007, 315(3): 266-281.
  • 3Petcdik MCH. Vitamin D and calcium insufficiency-related chronic diseases: molecular and[J]. Eur J Clin Nutr,2009,63(12): 1377-1386.
  • 4Garg M, Lubel JS, Sparrow MP, et al. Review article: vitamin D and inflammatory bowel disease-established concepts and future directions[J]. Aliment Pharmacol Ther, 2012, 36(4): 324-344.
  • 5欧阳钦,胡品津,钱家鸣,郑家驹,胡仁伟.对我国炎症性肠病诊断治疗规范的共识意见[J].胃肠病学,2007,12(8):488-495. 被引量:751
  • 6Querfeld U. Vitamin D and inflammation[J]. Pediatr Nephrol, 2013, 28(4): 605-610.
  • 7Cantoma MT. Why do T cells express the vitamin D receptor[J]. Ann NY Aead Sei, 2011, 1217: 77-82.
  • 8Chalmers JD, Mchugh BJ, Doeherty C. Vitamin-D deficiency isassociated with chronic bacterial colonsation and disease severity in bronchiectasis[J]. Thorax, 2013, 68(1): 39-47.
  • 9Bamias G, Kaltsa G, Ladas SD. Cytokines in the pathogenesis of ulcerative colitis[J]. Discov Med, 2011, 11(60): 459-467.
  • 10Ojaimi S, Skinner NA, Strauss BJ, et al. Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: a pilot study[J]. J Transl Med, 2013, 22; 11:176.

二级参考文献18

  • 1潘国宗 刘彤华 见:潘国宗 曹世植9. 主编.溃疡性结肠炎[A].见:潘国宗,曹世植9.,主编.现代胃肠病学.第Ⅰ版[C].北京:科学出版社,1994.1246-1247.
  • 2潘国宗 刘彤华.Crohn病[A].见:潘国宗 曹世植 主编.现代胃肠病学[C].北京:科学出版社,1994.1154.
  • 3Ouyang Q,Tandon R,Goh KL,et al.The emergence of inflammatory bowel disease in the Asian Pacific region.Curr Opin Gastroenterol,2005,21 (4):408-413.
  • 4Satsangi J,Silverberg MS,Vermeire S,et al.The Montreal classification of inflammatory bowel disease:controversies,consensus,and implications.Gut,2006,55(6):749-753.
  • 5Kornbluth A,Sachar DB; Practice Parameters Committee of the American College of Gastroenterology.Ulcerative colitis practice guidelines in adults (update):American College of Gastroenterology,Practice Parameters Committee.Am J Gastroenterol,2004,99 (7):1371-1385.
  • 6Hanauer SB,Sandborn W; Practice Parameters Committee of the American College of Gastroenterology.Management of Crohn's disease in adults.Am J Gastroenterol,2001,96 (3):635-643.
  • 7Stange EF,Travis SP,Vermeire S,et al.European Crohn's and Colitis Organisation.European evidence based consensus on the diagnosis and management of Crohn's disease:definitions and diagnosis.Gut,2006,55Suppl 1:i1-i15.
  • 8Carter MJ,Lobo AJ,Travis SP; IBD Section,British Society of Gastroenterology.Guidelines for the management of inflammatory bowel disease in adults.Gut,2004,53 Suppl 5:V1-V16.
  • 9Shivananda S,Hordijk ML,Ten Kate FJ,et al.Differential diagnosis of inflammatory bowel disease.A comparison of various diagnostic classifications.Scand J Gastroenterol,1991,26 (2):167-173.
  • 10樋渡信夫 渡边浩光 前川浩树 等.溃疡性结肠炎的诊断标准与诊断进展[J].炎症性肠疾患胃与肠,1997,32(3):271-278.

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  • 1宋春梅,马洪波,杜鹃,葛红娟,张晓辉.吉林地区某高校学生维生素B_1、B_2、C营养状况调查[J].吉林医药学院学报,2012,33(2):69-71. 被引量:3
  • 2Kong J,Zhang Z,Musch MW,et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier[ J ]. AJP-Gastrointest Liver Physiol, 2008,294 ( 1 ) : G208-G216.
  • 3Lim WC, Hanauer SB, Li YC. Mechanisms of disease: vitamin D andinflammatory bowel disease [ J ]. Nature Clin Pract Gas- troenterol Hepato1,2005,2 : 308 -315.
  • 4Kallay E, Pietschmann P, Toyokuni S, et al. Characterization of a vitamin Dreceptor knockout mouse as a model of colorec- tal hyperproliferation and DNA damage [ J ]. Carcinogenesis, 2001,22 (9) : 1429-1435.
  • 5Froicu M, Cantorna MT. Vitamin D and the vitamin D receptor arecritical for control of the innate immune response to colonic injury[ J]. BMC Immuno,2007 ,18 :5.
  • 6Guo XQ, Wang S J, Zhang LW, et al. DNA methylation and loss of protein expression in esophageal squamous cellcarcino- genesis of high-risk area[ J]. Exp Clin Cancer Res,2007,26: 587 -594.
  • 7Crivori P, Reinach B, Pezzetta D, et al. Computational models for identifying potential P-glycoprotein substrates and inhibi- tors[J]. Mol Pharm,2006,3 ( 1 ) :33.
  • 8Shirasaka Y, Kawasaki M, Sakane T, et al. Induction of human P-gly-coprotein in Caco-2 cells : development of a highly sensi- tive assay system for P-glycoprotein-mediated dmg transport [ J]. Drug Metab Pharmacokinet,2006,21 (5) :414.
  • 9Yamashita S, Furubayashi, Kataoka M, et al. Optimized condi- tions for prediction of intestinal drug permeability using Caco- 2 cells[J]. Eur J Pharm Sci,2000,10(3) ;195.
  • 10Fossati L, Dechaume R, Hardillier E, et al. Use of simulated intestinal fluid for Caco-2 permeability assay of lipophilic drugs [J]. Int J Pharm,2008,360(1-2) :148.

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