溃疡性结肠炎患者血清25(OH)维生素D水平与疾病活动性的相关性

Association of serum 25 (OH) vitamin D levels with ulcerative colitis activity

目的检测溃疡性结肠炎患者血清25(OH)维生素D水平,并分析25(OH)维生素D水平与疾病活动性的关系,探讨其临床意义。方法选择40例溃疡性结肠炎患者和30例健康对照者为研究对象,采用ELISA法检测溃疡性结肠炎患者和健康体检者血清中25(OH)维生素D水平,应用Mayo评分法对UC病人的疾病活动度进行分级,将维生素D水平与UC患者临床资料以及疾病活动度进行相关性分析。结果溃疡性结肠炎患者血清25(OH)维生素D水平(15.8±12.3)ng/ml明显低于健康对照组(42.5±26.7)ng/ml,p<0.05,血清25(OH)维生素D水平与患者年龄、性别、病程、是否吸烟、抗生素的应用、5-氨基水杨酸的应用及非甾体类抗炎药的应用无相关性,但与皮质类固醇激素的应用及溃疡性结肠炎的活动性相关。结论溃疡性结肠炎患者低储备维生素D水平与疾病活动性及皮质类固醇激素的应用相关。

Objective To determine serum 25（0H） vitamin D levels in patients with ulcerative colitis（UC） and analyze the association of serum 25（OH） vitamin D concentrations with disease activity. Methods A total of 40 ulcerative colitis patients and 30 healthy controls were enrolled in the study, 25（0H） vitamin D serum concentrations were measured by ELISA kit, clinical disease activity was calculated using the Mayo index, the relationship of vitamin D levels with clinical data and clinical disease activity was analyzed. Results Serum Vitamin D levels were found to be lower in patients with ulcerative colitis（15.8 ± 12.3）ng/ml than in healthy controls（42.5± 26.7）ng/ml, （P 〈0.05）, but not related significantly to patients age, gender, average duration of UC diagnosis, current medication antibiotics NSAIDs and 5-ASA, however, related significantly to the medication of Steroids and disease activity. Conclusion Vitamin D deficiency in patients with active ulcerative colitis is related to the medication of Steroids and disease activity.