血睾酮水平与男性甲状腺功能亢进症伴周期性麻痹的关系

Relationship between serum testosterone level and hypokalemic myoparalysis in male patients with hyperthyroidism

目的探讨毒性弥漫性甲状腺肿(Graves病)患者血睾酮水平与周期性麻痹的关系。方法选择男性甲状腺机能亢进症伴周期性麻痹(TPP组)患者组30例,单纯甲状腺机能亢进症(单纯甲亢组)患者组30例,比较两组组间血睾酮水平及相关实验室指标变化。结果 TPP组体质量指数(body mass index,BMI)、血睾酮高于单纯甲亢组(P<0.05),游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)低于单纯甲亢组(P<0.05)。结论 TTP患者存在高睾酮血症,血清钾下降可能与血清睾酮增高、血钾向细胞内转移有关。

Objective To investigate the relationship between serum testosterone level and hypokalemic myoparalysis in male patients with Graves＇ hyperthyroidism. Methods Sixty male patients with hyperthyroidism, including 30 patients with thyrotoxic periodic paralysis （TPP） and 30 patients without TPP, were enrolled in the study. Serum testosterone levels and other relevant laboratory parameters were compared between two groups. Results BMI and serum testosterone levels were significantly higher and FT3, FT41evels were significantly lower in TPP group than those in non- TPP group （ all P 〈 0. 05 ）. Conclusion High serum testosterone levels may be associated with hypokalemic paralysis in male hyperthyroidism patients. [ Key words] hyperthyroidism; Graves＇ disease; testosterone; periodic paralysis