黄斑格栅样激光光凝联合玻璃体腔注射曲安奈德治疗糖尿病性黄斑水肿的疗效分析

Therapeutic effect of macular laser grid photocoagulation and intravitreal triamcinolone acetonide on diabetic macular edema

目的评价黄斑格栅样激光光凝联合玻璃体腔注射曲安奈德(IVTA)对糖尿病性黄斑水肿(DME)的治疗效果。方法将DME患者48例(60眼)分成A、B、C组,每组20眼,A组行单纯黄斑区格栅样激光光凝治疗,B组行单纯IVTA治疗,C组在IVTA 4 mg后2周行黄斑区格栅样激光光凝。观察3组治疗前及治疗后1、3、6个月的视力,黄斑中心凹厚度。结果 3组患者治疗前视力、黄斑中心凹厚度差异均无统计学意义(P>0.05),3组治疗后1、3、6个月,视力、黄斑中心凹厚度比较:A组与B组差异无统计学意义(P>0.05),A、B组分别与C组比较差异有统计学意义(P<0.05)。结论黄斑格栅样激光光凝联合IVTA优于单纯激光及单纯玻璃体腔注药。(中国眼耳鼻喉科杂志,2014,14:92-95)

Objective To evaluate the clinical outcome of macular laser grid photocoagulation （MLGP） combined intravitreal triamc acetonide（IVTA）for diabetic macular edema （DME）. Methods Sixty eyes of 48 patients with diabetic macular edema were randomly divided into three groups：the A group was treated with simple macular laser grid photocoagulation （n = 20） ;the B group was treated with intravitreal triamcinoloue acetonide （IVTA） （n = 20） ;the C group was treated with macular laser grid photocoagulation 2 weeks after 4 mg IVTA. Then the visual acuity and macular thickness of the eyes in three groups were observed 1,3 and 6 months after treatment. Results The visual acuity, macular thickness of the eyes in three groups before treatment showed no significant difference （ P 〉 0.05 ）. The visual acuity, macular thickness of the eyes in group A, B were better after treatment, however there was no statistically significant difference（P 〉 0.05 ）. The visual acuity and macular thickness of the eyes in group C were better than those of group A and B with significant differences （ P 〈 0. 05 ）. Conclusions IVTA combined with macular laser grid photocoagulation is superior to simple laser photocoagulation and IVTA. （Chin J Ophthalmol and Otorhinolaryngo1,2014, 14：92-95 ）