2-(3α,7α-二乙酰氧基24-失碳-5β-胆甾烷)-5-苄氧甲基2-噁唑啉的合成

Synthesis of 2 (3α,7α diacetoxy 24 nor 5β cholanyl) 5 benzyloxymethyl 2 oxazoline

介绍新的鹅脱氧胆酸唑啉衍生物的合成 ,它是通过鹅脱氧胆酸与 1 苄氧基 3 氨基 2 丙醇之间的脱水环合反应 。

diacetoxy 24 nor 5β cholanyl) 5 benzyloxymethyl 2 oxazoline,which was a novel analogue of 2 (3α,7α dihydroxy 24 nor 5β cholanyl) 4,4 dimethyl 2 oxazoline,promisingly employed in the dissolution of cholesterol gallstones,was prepared by the direct cyclization of chenodeoxycholic acid with 1 benzyloxy 3 amino 2 propanol catalyzed by boric acid,followed by the acetylation with acetic anhydride in the presence of pyridine.