口服阿昔洛韦联合玻璃酸钠及氟米龙眼液治疗带状疱疹性角膜炎

Observation of oral acyclovir combined with sodium hyaluronate and fluorometholone eye drops on the treatment of herpes zoster keratitis

目的：探讨口服阿昔洛韦联合玻璃酸钠及氟米龙眼液滴眼治疗带状疱疹性角膜炎疗效。 方法：将本院收治的40例眼部带状疱疹患者分为两组，观察组20例，对照组20例。观察组应用阿昔洛韦200 mg口服，5次／d，玻璃酸钠眼液点眼，4次／d，当发生角膜基质炎、盘状角膜炎或者角膜内皮炎时使用1g／L氟米龙眼液点眼，4次／d；对照组给予1．5g／L更昔洛韦眼用凝胶滴眼4次／d。随访3～4 wk ，观察两组患者的疗效。 结果：观察组在患者局部疼痛及畏光缓解时间、角膜损伤愈合时间与对照组比较，观察组均优于对照组，差异有统计学意义（P＜0．05）；两组有效率比较，差异无统计学意义（ P＝0．633）。 结论：口服阿昔洛韦联合玻璃酸钠及氟米龙眼液治疗带状疱疹性角膜炎疗效满意。

AIM： To explore the effects of oral acyclovir combined with sodium hyaluronate and fluorometholone eye drops on the treatment of herpes zoster keratitis. METHODS：Forty patients with ocular herpes zoster were divided into two groups, 20 cases in the observation group, 20 cases in the control group.Observation group was treated with 200mg oral acyclovir for 5 times a day and sodium hyaluronate eye drops for 4 times a day. When stromal keratitis, disciform keratitis or corneal endotheliitis occurred, fluorometholone was used for 4 times a day. The control group was treated with ganciclovir ophthalmic gel for 4 times a day.The efficacy of two groups was observed, patients were followed up for 3-4wk. RESULTS：The observation group of local pain and photophobia in remission time and corneal damage healing time were better than control group, and there were significant differences （P〈0.05）.There was efficient comparison, but no statistically significant difference. CONCLUSION： Effects of oral acyclovir combined with sodium hyaluronate and fluorometholone eye drops on the treatment of herpes zoster keratitis are satisfactory.